Gene description for Adrbk1
Gene name adrenergic receptor kinase, beta 1
Gene symbol Adrbk1
Other names/aliases Adrbk-1
Bark-1
GRK2
beta ARK
betaARK1
Species Mus musculus
 Database cross references - Adrbk1
ExoCarta ExoCarta_110355
Vesiclepedia VP_110355
Entrez Gene 110355
UniProt Q99MK8  
 Adrbk1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Adrbk1
Molecular Function
    protein binding GO:0005515 IPI
    G-protein coupled receptor kinase activity GO:0004703 ISO
    nucleotide binding GO:0000166 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
    transferase activity GO:0016740 IEA
    protein kinase activity GO:0004672 IDA
    ATP binding GO:0005524 IEA
    kinase activity GO:0016301 IEA
    beta-adrenergic receptor kinase activity GO:0047696 ISO
    Edg-2 lysophosphatidic acid receptor binding GO:0031755 ISO
Biological Process
    viral entry into host cell GO:0046718 ISO
    tachykinin receptor signaling pathway GO:0007217 ISO
    response to oxidative stress GO:0006979 ISO
    peptidyl-serine phosphorylation GO:0018105 IDA
    G-protein coupled receptor signaling pathway GO:0007186 ISO
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    viral genome replication GO:0019079 ISO
    positive regulation of catecholamine secretion GO:0033605 ISO
    negative regulation of the force of heart contraction by chemical signal GO:0003108 ISO
    phosphorylation GO:0016310 IEA
    negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 ISO
    peptidyl-threonine phosphorylation GO:0018107 IDA
    protein phosphorylation GO:0006468 ISO
    negative regulation of striated muscle contraction GO:0045988 ISO
    follicle-stimulating hormone signaling pathway GO:0042699 ISO
    response to organic cyclic compound GO:0014070 ISO
    desensitization of G-protein coupled receptor protein signaling pathway GO:0002029 ISO
    regulation of the force of heart contraction GO:0002026 IGI
    heart development GO:0007507 IMP
    signal transduction GO:0007165 IEA
    cardiac muscle contraction GO:0060048 ISO
    receptor internalization GO:0031623 ISO
Subcellular Localization
    basolateral plasma membrane GO:0016323 ISO
    dendritic spine GO:0043197 ISO
    apical plasma membrane GO:0016324 ISO
    synapse GO:0045202 ISO
    axon GO:0030424 ISO
    dendritic shaft GO:0043198 ISO
    membrane GO:0016020 ISO
    caveola GO:0005901 ISO
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Adrbk1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Adrbk1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here