Gene description for Qdpr
Gene name quinoid dihydropteridine reductase
Gene symbol Qdpr
Other names/aliases 2610008L04Rik
D5Ertd371e
Dhpr
PKU2
Species Mus musculus
 Database cross references - Qdpr
ExoCarta ExoCarta_110391
Entrez Gene 110391
UniProt Q8BVI4  
 Qdpr identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
Pancreatic cells 19351151    
 Gene ontology annotations for Qdpr
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    NADPH binding GO:0070402 ISO
    6,7-dihydropteridine reductase activity GO:0004155 ISO
    NADH binding GO:0070404 ISO
    oxidoreductase activity GO:0016491 IEA
Biological Process
    oxidation-reduction process GO:0055114 ISO
    tetrahydrobiopterin biosynthetic process GO:0006729 ISO
    metabolic process GO:0008152 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 ISO
    neuron projection GO:0043005 ISO
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Qdpr in exosomes
1
Experiment ID 33
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Qdpr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Qdpr is involved
PathwayEvidenceSource
Phenylalanine and tyrosine catabolism IEA Reactome





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