Gene description for Apoa1
Gene name	apolipoprotein A-I
Gene symbol	Apoa1
Other names/aliases	Alp-1 Apoa-1 Brp-14 Ltw-1 Lvtw-1 Sep-1 Sep-2 Sep2 apo-AI apoA-I
Species	Mus musculus
Database cross references - Apoa1
ExoCarta	ExoCarta_11806
Vesiclepedia	VP_11806
Entrez Gene	11806
UniProt	Q00623
Apoa1 identified in exosomes derived from the following tissue/cell type
Faeces	33431899
Faeces	33431899

Gene ontology annotations for Apoa1

Molecular Function     amyloid-beta binding GO:0001540 IEA     amyloid-beta binding GO:0001540 ISO     signaling receptor binding GO:0005102 ISO     lipid transporter activity GO:0005319 IDA     lipid transporter activity GO:0005319 IMP     protein binding GO:0005515 IPI     phospholipid binding GO:0005543 IBA     phospholipid binding GO:0005543 IEA     phospholipid binding GO:0005543 ISO     high-density lipoprotein particle binding GO:0008035 IDA     lipid binding GO:0008289 IDA     cholesterol binding GO:0015485 IEA     cholesterol binding GO:0015485 ISO     enzyme binding GO:0019899 IEA     enzyme binding GO:0019899 ISO     heat shock protein binding GO:0031072 IEA     heat shock protein binding GO:0031072 ISO     apolipoprotein receptor binding GO:0034190 ISO     apolipoprotein A-I receptor binding GO:0034191 IEA     apolipoprotein A-I receptor binding GO:0034191 ISO     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISS     chemorepellent activity GO:0045499 IEA     chemorepellent activity GO:0045499 ISO     lipase inhibitor activity GO:0055102 ISO     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IBA     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IEA     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 ISO     high-density lipoprotein particle receptor binding GO:0070653 IEA     high-density lipoprotein particle receptor binding GO:0070653 ISO     lipoprotein particle binding GO:0071813 IDA     cholesterol transfer activity GO:0120020 IDA     cholesterol transfer activity GO:0120020 ISO     cholesterol transfer activity GO:0120020 ISO Biological Process     regulation of protein phosphorylation GO:0001932 IDA     endothelial cell proliferation GO:0001935 IMP     negative regulation of cytokine production involved in immune response GO:0002719 IEA     negative regulation of cytokine production involved in immune response GO:0002719 ISO     phospholipid metabolic process GO:0006644 IMP     phosphatidylcholine biosynthetic process GO:0006656 IEA     phosphatidylcholine biosynthetic process GO:0006656 ISO     cholesterol biosynthetic process GO:0006695 IMP     G protein-coupled receptor signaling pathway GO:0007186 IEA     G protein-coupled receptor signaling pathway GO:0007186 ISO     integrin-mediated signaling pathway GO:0007229 IEA     integrin-mediated signaling pathway GO:0007229 ISO     protein localization GO:0008104 IMP     cholesterol metabolic process GO:0008203 IBA     cholesterol metabolic process GO:0008203 IGI     cholesterol metabolic process GO:0008203 IMP     cholesterol metabolic process GO:0008203 ISO     glucocorticoid metabolic process GO:0008211 IMP     negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IEA     negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 ISO     positive regulation of cholesterol efflux GO:0010875 ISO     positive regulation of cholesterol efflux GO:0010875 ISS     negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 IEA     negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 ISO     phospholipid transport GO:0015914 ISO     protein oxidation GO:0018158 ISO     protein oxidation GO:0018158 ISS     peptidyl-methionine modification GO:0018206 ISO     peptidyl-methionine modification GO:0018206 ISS     lipid storage GO:0019915 IMP     regulation of intestinal cholesterol absorption GO:0030300 IDA     cholesterol transport GO:0030301 IDA     cholesterol transport GO:0030301 IMP     cholesterol transport GO:0030301 ISO     cholesterol transport GO:0030301 ISO     adrenal gland development GO:0030325 IMP     animal organ regeneration GO:0031100 ISO     axon regeneration GO:0031103 IGI     regulation of Cdc42 protein signal transduction GO:0032489 IEA     regulation of Cdc42 protein signal transduction GO:0032489 ISO     negative regulation of interleukin-1 beta production GO:0032691 IEA     negative regulation of interleukin-1 beta production GO:0032691 ISO     cholesterol efflux GO:0033344 IBA     cholesterol efflux GO:0033344 IDA     cholesterol efflux GO:0033344 IMP     cholesterol efflux GO:0033344 ISO     phospholipid efflux GO:0033700 IBA     phospholipid efflux GO:0033700 IEA     phospholipid efflux GO:0033700 ISO     negative regulation of heterotypic cell-cell adhesion GO:0034115 IEA     negative regulation of heterotypic cell-cell adhesion GO:0034115 ISO     high-density lipoprotein particle remodeling GO:0034375 IEA     high-density lipoprotein particle remodeling GO:0034375 ISO     high-density lipoprotein particle assembly GO:0034380 IEA     high-density lipoprotein particle assembly GO:0034380 ISO     positive regulation of Rho protein signal transduction GO:0035025 IEA     positive regulation of Rho protein signal transduction GO:0035025 ISO     lipoprotein biosynthetic process GO:0042158 IGI     lipoprotein biosynthetic process GO:0042158 IMP     cholesterol homeostasis GO:0042632 IEA     cholesterol homeostasis GO:0042632 ISO     blood vessel endothelial cell migration GO:0043534 IMP     reverse cholesterol transport GO:0043691 IEA     reverse cholesterol transport GO:0043691 ISO     negative regulation of inflammatory response GO:0050728 IEA     negative regulation of inflammatory response GO:0050728 ISO     positive regulation of phagocytosis GO:0050766 ISO     positive regulation of phagocytosis GO:0050766 ISS     protein stabilization GO:0050821 ISO     protein stabilization GO:0050821 ISS     negative chemotaxis GO:0050919 IEA     negative chemotaxis GO:0050919 ISO     vitamin transport GO:0051180 IEA     vitamin transport GO:0051180 ISO     positive regulation of hydrolase activity GO:0051345 ISO     negative regulation of hydrolase activity GO:0051346 IGI     positive regulation of transferase activity GO:0051347 IMP     positive regulation of stress fiber assembly GO:0051496 IEA     positive regulation of stress fiber assembly GO:0051496 ISO     acylglycerol homeostasis GO:0055090 IBA     phospholipid homeostasis GO:0055091 IEA     phospholipid homeostasis GO:0055091 ISO     negative regulation of cell adhesion molecule production GO:0060354 IEA     negative regulation of cell adhesion molecule production GO:0060354 ISO     negative regulation of response to cytokine stimulus GO:0060761 ISO     triglyceride homeostasis GO:0070328 IEA     triglyceride homeostasis GO:0070328 ISO     cholesterol import GO:0070508 IEA     cholesterol import GO:0070508 ISO     cellular response to lipoprotein particle stimulus GO:0071402 IEA     positive regulation of cholesterol metabolic process GO:0090205 IEA     positive regulation of cholesterol metabolic process GO:0090205 ISO     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IEA     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO     positive regulation of phospholipid efflux GO:1902995 ISO     positive regulation of phospholipid efflux GO:1902995 ISS     positive regulation of CoA-transferase activity GO:1905920 ISO Subcellular Localization     extracellular region GO:0005576 IDA     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     cytosol GO:0005829 TAS     cell surface GO:0009986 ISO     endocytic vesicle GO:0030139 IEA     endocytic vesicle GO:0030139 ISO     cytoplasmic vesicle GO:0031410 ISO     very-low-density lipoprotein particle GO:0034361 IBA     very-low-density lipoprotein particle GO:0034361 IEA     very-low-density lipoprotein particle GO:0034361 ISO     low-density lipoprotein particle GO:0034362 IBA     low-density lipoprotein particle GO:0034362 ISO     intermediate-density lipoprotein particle GO:0034363 ISO     high-density lipoprotein particle GO:0034364 IBA     high-density lipoprotein particle GO:0034364 ISO     discoidal high-density lipoprotein particle GO:0034365 ISO     spherical high-density lipoprotein particle GO:0034366 IEA     spherical high-density lipoprotein particle GO:0034366 ISO     chylomicron GO:0042627 IBA     extracellular vesicle GO:1903561 IBA