Gene description for TREH
Gene name trehalase (brush-border membrane glycoprotein)
Gene symbol TREH
Other names/aliases TRE
TREA
Species Homo sapiens
 Database cross references - TREH
ExoCarta ExoCarta_11181
Vesiclepedia VP_11181
Entrez Gene 11181
HGNC 12266
MIM 275360
UniProt O43280  
 TREH identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for TREH
Molecular Function
    alpha,alpha-trehalase activity GO:0004555 IDA
Biological Process
    organ morphogenesis GO:0009887 IEA
    small molecule metabolic process GO:0044281 TAS
    trehalose catabolic process GO:0005993 TAS
    carbohydrate metabolic process GO:0005975 TAS
    trehalose metabolic process GO:0005991 NAS
    polysaccharide digestion GO:0044245 TAS
Subcellular Localization
    anchored component of plasma membrane GO:0046658 TAS
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified TREH in exosomes
1
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
MISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
MISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TREH
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TREH is involved
PathwayEvidenceSource
Digestion of dietary carbohydrate TAS Reactome





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