Gene description for Egln1
Gene name egl-9 family hypoxia-inducible factor 1
Gene symbol Egln1
Other names/aliases AI503754
Species Mus musculus
 Database cross references - Egln1
ExoCarta ExoCarta_112405
Entrez Gene 112405
UniProt Q91YE3  
 Egln1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Egln1
Molecular Function
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 ISO
    enzyme binding GO:0019899 ISO
    dioxygenase activity GO:0051213 IEA
    peptidyl-proline 4-dioxygenase activity GO:0031545 ISO
    oxidoreductase activity GO:0016491 IEA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 IEA
    L-ascorbic acid binding GO:0031418 IEA
    metal ion binding GO:0046872 IEA
    peptidyl-proline dioxygenase activity GO:0031543 ISO
    iron ion binding GO:0005506 IEA
Biological Process
    negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344 ISO
    oxidation-reduction process GO:0055114 ISO
    cardiac muscle tissue morphogenesis GO:0055008 IMP
    response to hypoxia GO:0001666 ISO
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 ISO
    regulation of angiogenesis GO:0045765 IMP
    ventricular septum morphogenesis GO:0060412 IMP
    peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0018401 ISO
    oxygen homeostasis GO:0032364 ISO
    heart trabecula formation GO:0060347 IMP
    response to nitric oxide GO:0071731 ISO
    labyrinthine layer development GO:0060711 IMP
    negative regulation of cAMP catabolic process GO:0030821 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Egln1 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Egln1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Egln1 is involved
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha IEA Reactome

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