Gene description for SCN11A
Gene name sodium channel, voltage gated, type XI alpha subunit
Gene symbol SCN11A
Other names/aliases FEPS3
HSAN7
NAV1.9
NaN
PN5
SCN12A
SNS-2
Species Homo sapiens
 Database cross references - SCN11A
ExoCarta ExoCarta_11280
Entrez Gene 11280
HGNC 10583
MIM 604385
UniProt Q9UI33  
 SCN11A identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SCN11A
Molecular Function
    voltage-gated sodium channel activity GO:0005248 IEA
Biological Process
    neuronal action potential GO:0019228 IBA
    membrane depolarization during action potential GO:0086010 IBA
    regulation of ion transmembrane transport GO:0034765 IEA
    regulation of sensory perception of pain GO:0051930 ISS
    response to drug GO:0042493 TAS
    sodium ion transmembrane transport GO:0035725 IBA
    sodium ion transport GO:0006814 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    C-fiber GO:0044299 IEA
    plasma membrane GO:0005886 IBA
    voltage-gated sodium channel complex GO:0001518 IEA
 Experiment description of studies that identified SCN11A in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SCN11A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SCN11A is involved
PathwayEvidenceSource
Interaction between L1 and Ankyrins TAS Reactome





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