Gene description for SCN11A
Gene name sodium channel, voltage gated, type XI alpha subunit
Gene symbol SCN11A
Other names/aliases FEPS3
HSAN7
NAV1.9
NaN
PN5
SCN12A
SNS-2
Species Homo sapiens
 Database cross references - SCN11A
ExoCarta ExoCarta_11280
Vesiclepedia VP_11280
Entrez Gene 11280
HGNC 10583
MIM 604385
UniProt Q9UI33  
 SCN11A identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SCN11A
Molecular Function
    voltage-gated sodium channel activity GO:0005248 IBA
    voltage-gated sodium channel activity GO:0005248 IDA
    voltage-gated sodium channel activity GO:0005248 IMP
Biological Process
    thigmotaxis GO:0001966 IEA
    acute inflammatory response GO:0002526 IEA
    chronic inflammatory response GO:0002544 IEA
    axonogenesis GO:0007409 IEA
    circadian rhythm GO:0007623 IEA
    response to heat GO:0009408 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    response to toxic substance GO:0009636 IEA
    response to high light intensity GO:0009644 IEA
    response to auditory stimulus GO:0010996 IEA
    neuronal action potential GO:0019228 IEA
    sensory perception of pain GO:0019233 IMP
    sensory perception of pain GO:0019233 ISS
    response to prostaglandin E GO:0034695 IEA
    sodium ion transmembrane transport GO:0035725 IBA
    thermosensory behavior GO:0040040 IEA
    mast cell degranulation GO:0043303 IEA
    cell motility GO:0048870 IEA
    detection of temperature stimulus involved in sensory perception of pain GO:0050965 IEA
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IEA
    reflex GO:0060004 IEA
    micturition GO:0060073 IEA
    skeletal muscle organ development GO:0060538 IEA
    artery development GO:0060840 IEA
    behavioral response to acetic acid induced pain GO:0061367 IEA
    behavioral response to formalin induced pain GO:0061368 IEA
    cellular response to cold GO:0070417 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    response to nitric oxide GO:0071731 IEA
    cardiac muscle cell action potential involved in contraction GO:0086002 IBA
    membrane depolarization during action potential GO:0086010 IDA
    membrane depolarization during action potential GO:0086010 IMP
    action potential initiation GO:0099610 IEA
    cAMP/PKA signal transduction GO:0141156 IEA
    sensory perception of itch GO:0160025 IEA
    calcitonin gene-related peptide receptor signaling pathway GO:1990408 IEA
    small intestine smooth muscle contraction GO:1990770 IEA
Subcellular Localization
    voltage-gated sodium channel complex GO:0001518 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IMP
    axon GO:0030424 ISS
    neuronal cell body GO:0043025 IEA
    axonal growth cone GO:0044295 IEA
    C-fiber GO:0044299 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SCN11A in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SCN11A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DBN1 1627
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml



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