Gene description for MGAT4A
Gene name mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
Gene symbol MGAT4A
Other names/aliases GNT-IV
GNT-IVA
GnT-4a
Species Homo sapiens
 Database cross references - MGAT4A
ExoCarta ExoCarta_11320
Entrez Gene 11320
HGNC 7047
MIM 604623
UniProt Q9UM21  
 MGAT4A identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for MGAT4A
Molecular Function
    metal ion binding GO:0046872 IEA
    alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity GO:0008454 IEA
Biological Process
    post-translational protein modification GO:0043687 TAS
    N-glycan processing GO:0006491 TAS
    cellular protein metabolic process GO:0044267 TAS
    protein N-linked glycosylation via asparagine GO:0018279 TAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified MGAT4A in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for MGAT4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MGAT4A is involved
PathwayEvidenceSource
N-Glycan antennae elongation TAS Reactome





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