Gene description for Prss1
Gene name protease, serine 1 (trypsin 1)
Gene symbol Prss1
Other names/aliases Try-1
Try1
Trygn16
Species Mus musculus
 Database cross references - Prss1
ExoCarta ExoCarta_114228
Vesiclepedia VP_114228
Entrez Gene 114228
 Prss1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Prss1
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 ISO
    calcium ion binding GO:0005509 ISO
    serine-type peptidase activity GO:0008236 IDA
Biological Process
    proteolysis GO:0006508 IBA
Subcellular Localization
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Prss1 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Prss1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nphp3  
Affinity Capture-MS Mus musculus
2 MAPT  
Reconstituted Complex Homo sapiens
3 Nphp4  
Affinity Capture-MS Mus musculus
4 Serpina1a 20700
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Prss1 is involved
No pathways found





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