Gene description for Serpina1a
Gene name serine (or cysteine) peptidase inhibitor, clade A, member 1A
Gene symbol Serpina1a
Other names/aliases Aat-2
Aat2
Dom1
PI1
Spi1-1
Spi1-3
Species Mus musculus
 Database cross references - Serpina1a
ExoCarta ExoCarta_20700
Vesiclepedia VP_20700
Entrez Gene 20700
UniProt P07758  
 Serpina1a identified in sEVs derived from the following tissue/cell type
Brain cancer cells 19109410    
 Gene ontology annotations for Serpina1a
Molecular Function
    protease binding GO:0002020 ISO
    endopeptidase inhibitor activity GO:0004866 ISO
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 ISO
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
Biological Process
    protein N-linked glycosylation GO:0006487 IDA
    acute-phase response GO:0006953 IEA
    response to lead ion GO:0010288 ISO
    response to methanol GO:0033986 ISO
    response to cytokine GO:0034097 IDA
    response to peptide hormone GO:0043434 IDA
    response to chromate GO:0046687 ISO
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    endoplasmic reticulum GO:0005783 ISO
    Golgi apparatus GO:0005794 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified Serpina1a in sEVs
1
Experiment ID 26
MISEV standards
EM
Biophysical techniques
Alix|GAPDH|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors "Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD"
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
 Protein-protein interactions for Serpina1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Prss1 114228
Reconstituted Complex Mus musculus
2 Cela1  
Reconstituted Complex Mus musculus
3 Elane  
Reconstituted Complex Mus musculus
4 Fancd2  
Affinity Capture-MS Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Serpina1a is involved
No pathways found





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