Gene description for SLITRK1
Gene name SLIT and NTRK-like family, member 1
Gene symbol SLITRK1
Other names/aliases LRRC12
TTM
Species Homo sapiens
 Database cross references - SLITRK1
ExoCarta ExoCarta_114798
Vesiclepedia VP_114798
Entrez Gene 114798
HGNC 20297
MIM 609678
UniProt Q96PX8  
 SLITRK1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SLITRK1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endocytosis GO:0006897 IEA
    axonogenesis GO:0007409 IBA
    synapse assembly GO:0007416 IMP
    gene expression GO:0010467 IEA
    adult behavior GO:0030534 IEA
    multicellular organism growth GO:0035264 IEA
    norepinephrine metabolic process GO:0042415 IEA
    homeostatic process GO:0042592 IEA
    positive regulation of axonogenesis GO:0050772 IMP
    positive regulation of synapse assembly GO:0051965 IBA
    vocalization behavior GO:0071625 IEA
    synaptic membrane adhesion GO:0099560 IDA
    synaptic membrane adhesion GO:0099560 IMP
    regulation of presynapse assembly GO:1905606 IDA
    regulation of presynapse assembly GO:1905606 IMP
    neuron projection extension GO:1990138 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    synapse GO:0045202 ISS
    postsynaptic density membrane GO:0098839 IBA
    glutamatergic synapse GO:0098978 IBA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    GABA-ergic synapse GO:0098982 IBA
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IMP
 Experiment description of studies that identified SLITRK1 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SLITRK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP4C 92421
Affinity Capture-MS Homo sapiens
2 UBQLN2 29978
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here