Gene description for Acvr2a
Gene name	activin receptor IIA
Gene symbol	Acvr2a
Other names/aliases	ActrIIa Acvr2 TactrII
Species	Mus musculus
Database cross references - Acvr2a
ExoCarta	ExoCarta_11480
Vesiclepedia	VP_11480
Entrez Gene	11480
UniProt	P27038
Acvr2a identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Acvr2a

Molecular Function     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 ISO     protein serine/threonine kinase activity GO:0004674 TAS     transforming growth factor beta receptor activity, type I GO:0005025 IEA     transforming growth factor beta receptor activity, type II GO:0005026 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     coreceptor activity GO:0015026 IEA     coreceptor activity GO:0015026 ISO     activin receptor activity, type I GO:0016361 IEA     activin receptor activity, type II GO:0016362 IEA     activin receptor activity GO:0017002 IDA     activin receptor activity GO:0017002 ISO     activin receptor activity GO:0017002 ISO     growth factor binding GO:0019838 IMP     growth factor binding GO:0019838 IPI     PDZ domain binding GO:0030165 IPI     inhibin binding GO:0034711 IPI     inhibin binding GO:0034711 ISO     identical protein binding GO:0042802 IPI     metal ion binding GO:0046872 IEA     activin binding GO:0048185 IPI     activin binding GO:0048185 ISO     activin binding GO:0048185 ISO     transforming growth factor beta receptor activity, type III GO:0070123 IEA     BMP receptor activity GO:0098821 IMP Biological Process     gastrulation with mouth forming second GO:0001702 IGI     positive regulation of protein phosphorylation GO:0001934 ISO     autophagy GO:0006914 ISO     spermatogenesis GO:0007283 IGI     determination of left/right symmetry GO:0007368 IGI     pattern specification process GO:0007389 IBA     mesoderm development GO:0007498 IGI     male gonad development GO:0008584 IMP     anterior/posterior pattern specification GO:0009952 IGI     regulation of signal transduction GO:0009966 IDA     positive regulation of bone mineralization GO:0030501 IEA     positive regulation of bone mineralization GO:0030501 ISO     BMP signaling pathway GO:0030509 IMP     BMP signaling pathway GO:0030509 IMP     BMP signaling pathway GO:0030509 ISO     BMP signaling pathway GO:0030509 ISO     activin receptor signaling pathway GO:0032924 IBA     activin receptor signaling pathway GO:0032924 IEA     activin receptor signaling pathway GO:0032924 ISO     positive regulation of activin receptor signaling pathway GO:0032927 IEA     positive regulation of activin receptor signaling pathway GO:0032927 ISO     odontogenesis of dentin-containing tooth GO:0042475 IGI     sperm ejaculation GO:0042713 IMP     penile erection GO:0043084 IMP     regulation of nitric oxide biosynthetic process GO:0045428 IMP     positive regulation of erythrocyte differentiation GO:0045648 IEA     positive regulation of erythrocyte differentiation GO:0045648 ISO     positive regulation of osteoblast differentiation GO:0045669 IEA     positive regulation of osteoblast differentiation GO:0045669 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of follicle-stimulating hormone secretion GO:0046881 ISO     embryonic skeletal system development GO:0048706 IMP     Sertoli cell proliferation GO:0060011 IMP     positive regulation of SMAD protein signal transduction GO:0060391 IEA     positive regulation of SMAD protein signal transduction GO:0060391 ISO     SMAD protein signal transduction GO:0060395 ISO     cellular response to growth factor stimulus GO:0071363 IBA     cellular response to BMP stimulus GO:0071773 ISO     cellular response to oxygen-glucose deprivation GO:0090650 ISO Subcellular Localization     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     inhibin-betaglycan-ActRII complex GO:0034673 IEA     inhibin-betaglycan-ActRII complex GO:0034673 ISO     receptor complex GO:0043235 IEA     receptor complex GO:0043235 ISO     activin receptor complex GO:0048179 IBA