Gene description for Tgfbr3
Gene name transforming growth factor, beta receptor III
Gene symbol Tgfbr3
Other names/aliases 1110036H20Rik
AU015626
AW215636
TBRIII
Species Mus musculus
 Database cross references - Tgfbr3
ExoCarta ExoCarta_21814
Vesiclepedia VP_21814
Entrez Gene 21814
UniProt O88393  
 Tgfbr3 identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34112803    
Breast cancer cells 34112803    
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tgfbr3
Molecular Function
    transmembrane signaling receptor activity GO:0004888 ISO
    transforming growth factor beta receptor activity GO:0005024 IBA
    transforming growth factor beta receptor activity GO:0005024 IDA
    transforming growth factor beta receptor activity GO:0005024 IMP
    transforming growth factor beta receptor activity GO:0005024 ISO
    type II transforming growth factor beta receptor binding GO:0005114 IBA
    type II transforming growth factor beta receptor binding GO:0005114 ISO
    transforming growth factor beta receptor binding GO:0005160 ISO
    protein binding GO:0005515 IPI
    glycosaminoglycan binding GO:0005539 IBA
    glycosaminoglycan binding GO:0005539 IDA
    heparin binding GO:0008201 ISO
    coreceptor activity GO:0015026 ISO
    fibroblast growth factor binding GO:0017134 ISO
    PDZ domain binding GO:0030165 IPI
    BMP binding GO:0036122 ISO
    SMAD binding GO:0046332 IMP
    SMAD binding GO:0046332 ISO
    activin binding GO:0048185 ISO
    transforming growth factor beta binding GO:0050431 IBA
    transforming growth factor beta binding GO:0050431 IDA
    transforming growth factor beta binding GO:0050431 ISO
    transforming growth factor beta binding GO:0050431 ISO
    transforming growth factor beta receptor activity, type III GO:0070123 ISO
Biological Process
    blood vessel development GO:0001568 IMP
    vasculogenesis GO:0001570 IMP
    osteoblast differentiation GO:0001649 IMP
    in utero embryonic development GO:0001701 IMP
    blastocyst development GO:0001824 IDA
    epithelial to mesenchymal transition GO:0001837 IBA
    epithelial to mesenchymal transition GO:0001837 ISO
    liver development GO:0001889 IMP
    blood vessel remodeling GO:0001974 IMP
    muscular septum morphogenesis GO:0003150 IMP
    outflow tract morphogenesis GO:0003151 IMP
    ventricular compact myocardium morphogenesis GO:0003223 IMP
    epicardial cell to mesenchymal cell transition GO:0003347 TAS
    immune response GO:0006955 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IGI
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    transforming growth factor beta receptor complex assembly GO:0007181 ISO
    cell population proliferation GO:0008283 IMP
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 IDA
    negative regulation of epithelial cell migration GO:0010633 IMP
    negative regulation of epithelial to mesenchymal transition GO:0010719 IMP
    cell migration GO:0016477 IBA
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IBA
    negative regulation of cell migration GO:0030336 ISO
    BMP signaling pathway GO:0030509 IMP
    BMP signaling pathway GO:0030509 ISO
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 ISO
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    positive regulation of BMP signaling pathway GO:0030513 IMP
    response to follicle-stimulating hormone GO:0032354 ISO
    collagen metabolic process GO:0032963 IGI
    response to prostaglandin E GO:0034695 ISO
    response to luteinizing hormone GO:0034699 ISO
    intracellular signal transduction GO:0035556 ISO
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 ISO
    regulation of JNK cascade GO:0046328 IMP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    roof of mouth development GO:0060021 IMP
    cardiac muscle cell proliferation GO:0060038 IMP
    positive regulation of cardiac muscle cell proliferation GO:0060045 IMP
    definitive hemopoiesis GO:0060216 IMP
    cardiac epithelial to mesenchymal transition GO:0060317 ISO
    definitive erythrocyte differentiation GO:0060318 IMP
    heart trabecula formation GO:0060347 IMP
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    positive regulation of SMAD protein signal transduction GO:0060391 ISO
    negative regulation of SMAD protein signal transduction GO:0060392 ISO
    ventricular septum morphogenesis GO:0060412 IMP
    apoptotic process involved in morphogenesis GO:0060561 IMP
    epicardium-derived cardiac fibroblast cell development GO:0060939 IMP
    coronary vasculature development GO:0060976 TAS
    coronary vasculature morphogenesis GO:0060977 TAS
    vasculogenesis involved in coronary vascular morphogenesis GO:0060979 IMP
    vasculogenesis involved in coronary vascular morphogenesis GO:0060979 TAS
    visceral serous pericardium development GO:0061032 TAS
    heart trabecula morphogenesis GO:0061384 IMP
    secondary palate development GO:0062009 IMP
    protein-containing complex assembly GO:0065003 ISO
    regulation of ERK1 and ERK2 cascade GO:0070372 IMP
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO
    blood vessel diameter maintenance GO:0097746 TAS
    negative regulation of extracellular matrix assembly GO:1901202 ISO
    negative regulation of apoptotic process involved in morphogenesis GO:1902338 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 IDA
    membrane GO:0016020 ISO
    inhibin-betaglycan-ActRII complex GO:0034673 ISO
    receptor complex GO:0043235 ISO
 Experiment description of studies that identified Tgfbr3 in sEVs
1
Experiment ID 520
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Cd9
Enriched markers
✔
Golga2
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name EO771
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 521
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Cd9
Enriched markers
✔
Golga2
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name PyMT
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tgfbr3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tgfbr2 21813
Affinity Capture-Western Mus musculus
2 Acvr2a 11480
Co-fractionation Mus musculus
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