Gene description for Tgfbr3
Gene name transforming growth factor, beta receptor III
Gene symbol Tgfbr3
Other names/aliases 1110036H20Rik
Species Mus musculus
 Database cross references - Tgfbr3
ExoCarta ExoCarta_21814
Entrez Gene 21814
UniProt O88393  
 Tgfbr3 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Tgfbr3
Molecular Function
    transforming growth factor beta receptor binding GO:0005160 ISO
    transforming growth factor beta binding GO:0050431 ISO
    type II transforming growth factor beta receptor binding GO:0005114 ISO
    glycosaminoglycan binding GO:0005539 IDA
    activin binding GO:0048185 ISO
    PDZ domain binding GO:0030165 IPI
    protein binding GO:0005515 IPI
    transforming growth factor beta receptor activity, type III GO:0070123 ISO
    transforming growth factor beta-activated receptor activity GO:0005024 ISO
    heparin binding GO:0008201 ISO
    SMAD binding GO:0046332 ISO
    fibroblast growth factor binding GO:0017134 ISO
    coreceptor activity GO:0015026 ISO
Biological Process
    transforming growth factor beta receptor complex assembly GO:0007181 ISO
    epicardial cell to mesenchymal cell transition GO:0003347 TAS
    blastocyst development GO:0001824 IDA
    cell growth GO:0016049 ISO
    negative regulation of epithelial cell migration GO:0010633 IMP
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    osteoblast differentiation GO:0001649 IMP
    response to follicle-stimulating hormone GO:0032354 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    embryo development GO:0009790 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    protein phosphorylation GO:0006468 IDA
    blood vessel remodeling GO:0001974 IMP
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 ISO
    cardiac epithelial to mesenchymal transition GO:0060317 ISO
    protein complex assembly GO:0006461 ISO
    negative regulation of epithelial to mesenchymal transition GO:0010719 IMP
    epithelial to mesenchymal transition GO:0001837 ISO
    blood vessel development GO:0001568 IMP
    pathway-restricted SMAD protein phosphorylation GO:0060389 ISO
    coronary vasculature morphogenesis GO:0060977 TAS
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    regulation of blood vessel size GO:0050880 TAS
    coronary vasculature development GO:0060976 TAS
    heart trabecula formation GO:0060347 IMP
    liver development GO:0001889 IMP
    negative regulation of cellular component movement GO:0051271 ISO
    definitive erythrocyte differentiation GO:0060318 IMP
    response to luteinizing hormone GO:0034699 ISO
    intracellular signal transduction GO:0035556 ISO
    cardiac muscle cell proliferation GO:0060038 IMP
    regulation of protein binding GO:0043393 ISO
    response to prostaglandin E GO:0034695 ISO
    negative regulation of apoptotic process involved in morphogenesis GO:1902338 IMP
    palate development GO:0060021 IMP
    in utero embryonic development GO:0001701 IMP
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    visceral serous pericardium development GO:0061032 TAS
    BMP signaling pathway GO:0030509 ISO
    definitive hemopoiesis GO:0060216 IMP
    positive regulation of BMP signaling pathway GO:0030513 IMP
    positive regulation of cell proliferation GO:0008284 IMP
    vasculogenesis involved in coronary vascular morphogenesis GO:0060979 TAS
    vasculogenesis GO:0001570 IMP
    immune response GO:0006955 ISO
Subcellular Localization
    external side of plasma membrane GO:0009897 ISO
    extracellular exosome GO:0070062 ISO
    inhibin-betaglycan-ActRII complex GO:0034673 ISO
    integral component of plasma membrane GO:0005887 TAS
    proteinaceous extracellular matrix GO:0005578 ISO
    integral component of membrane GO:0016021 ISO
    receptor complex GO:0043235 ISO
    extracellular space GO:0005615 ISO
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 ISO
    cell surface GO:0009986 IDA
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Tgfbr3 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tgfbr3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tgfbr3 is involved
No pathways found

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