Gene description for Adam10
Gene name	a disintegrin and metallopeptidase domain 10
Gene symbol	Adam10
Other names/aliases	1700031C13Rik MADM kuz kuzbanian
Species	Mus musculus
Database cross references - Adam10
ExoCarta	ExoCarta_11487
Entrez Gene	11487
UniProt	O35598
Adam10 identified in exosomes derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for Adam10

Molecular Function     zinc ion binding GO:0008270 IEA     protein kinase binding GO:0019901 IDA     protein homodimerization activity GO:0042803 IPI     metal ion binding GO:0046872 IEA     SH2 domain binding GO:0042169 NAS     hydrolase activity GO:0016787 IEA     endopeptidase activity GO:0004175 IDA     metalloendopeptidase activity GO:0004222 ISO     protein binding GO:0005515 IPI     SH3 domain binding GO:0017124 IEA     metallopeptidase activity GO:0008237 ISO     peptidase activity GO:0008233 IEA Biological Process     in utero embryonic development GO:0001701 IMP     proteolysis GO:0006508 IMP     positive regulation of cell proliferation GO:0008284 ISO     nucleocytoplasmic transport GO:0006913 NAS     membrane protein ectodomain proteolysis GO:0006509 ISO     positive regulation of cell growth GO:0030307 ISO     constitutive protein ectodomain proteolysis GO:0051089 ISO     response to tumor necrosis factor GO:0034612 ISO     positive regulation of cell migration GO:0030335 ISO     protein phosphorylation GO:0006468 IDA     Notch receptor processing GO:0007220 NAS     negative regulation of cell adhesion GO:0007162 ISO     Notch signaling pathway GO:0007219 IMP     monocyte activation GO:0042117 ISO     PMA-inducible membrane protein ectodomain proteolysis GO:0051088 ISO     positive regulation of T cell chemotaxis GO:0010820 ISO Subcellular Localization     Golgi-associated vesicle GO:0005798 ISO     Golgi apparatus GO:0005794 ISO     perinuclear endoplasmic reticulum GO:0097038 ISO     trans-Golgi network GO:0005802 ISO     cytoplasm GO:0005737 IDA     intracellular membrane-bounded organelle GO:0043231 ISO     nucleus GO:0005634 IDA     postsynaptic density GO:0014069 IDA     cell GO:0005623 NAS     cell surface GO:0009986 ISO     extracellular exosome GO:0070062 ISO     focal adhesion GO:0005925 ISO     membrane GO:0016020 ISO     intracellular GO:0005622 NAS     integral component of membrane GO:0016021 IEA     tetraspanin-enriched microdomain GO:0097197 ISO