Gene description for Adssl1
Gene name adenylosuccinate synthetase like 1
Gene symbol Adssl1
Other names/aliases AI528595
Adss
Adss1
Species Mus musculus
 Database cross references - Adssl1
ExoCarta ExoCarta_11565
Vesiclepedia VP_11565
Entrez Gene 11565
UniProt P28650  
 Adssl1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Adssl1
Molecular Function
    magnesium ion binding GO:0000287 IEA
    GTPase activity GO:0003924 ISO
    adenylosuccinate synthase activity GO:0004019 IBA
    adenylosuccinate synthase activity GO:0004019 IDA
    adenylosuccinate synthase activity GO:0004019 ISO
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
    identical protein binding GO:0042802 ISO
    actin filament binding GO:0051015 ISO
Biological Process
    purine nucleotide metabolic process GO:0006163 IDA
    AMP biosynthetic process GO:0006167 ISO
    aspartate metabolic process GO:0006531 ISO
    'de novo' AMP biosynthetic process GO:0044208 IBA
    'de novo' AMP biosynthetic process GO:0044208 IEA
    AMP salvage GO:0044209 IDA
    AMP salvage GO:0044209 TAS
    IMP metabolic process GO:0046040 IBA
    IMP metabolic process GO:0046040 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 IEA
 Experiment description of studies that identified Adssl1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Adssl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Adssl1 11565
Co-crystal Structure Mus musculus
Co-crystal Structure Mus musculus
View the network image/svg+xml



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