Gene description for Adssl1
Gene name adenylosuccinate synthetase like 1
Gene symbol Adssl1
Other names/aliases AI528595
Adss
Adss1
Species Mus musculus
 Database cross references - Adssl1
ExoCarta ExoCarta_11565
Vesiclepedia VP_11565
Entrez Gene 11565
UniProt P28650  
 Adssl1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Adssl1
Molecular Function
    adenylosuccinate synthase activity GO:0004019 ISO
    nucleotide binding GO:0000166 IEA
    GTPase activity GO:0003924 ISO
    ligase activity GO:0016874 IEA
    protein homodimerization activity GO:0042803 ISO
    GTP binding GO:0005525 IEA
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    IMP metabolic process GO:0046040 ISO
    purine nucleotide biosynthetic process GO:0006164 IEA
    'de novo' AMP biosynthetic process GO:0044208 IBA
    AMP biosynthetic process GO:0006167 ISO
    purine ribonucleoside monophosphate biosynthetic process GO:0009168 ISO
    purine nucleotide metabolic process GO:0006163 IDA
    aspartate metabolic process GO:0006531 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Adssl1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Adssl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adssl1 is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis IEA Reactome





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