Gene description for Ak2
Gene name adenylate kinase 2
Gene symbol Ak2
Other names/aliases Ak-2
D4Ertd220e
Species Mus musculus
 Database cross references - Ak2
ExoCarta ExoCarta_11637
Entrez Gene 11637
UniProt Q9WTP6  
 Ak2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Ak2
Molecular Function
    nucleotide binding GO:0000166 IEA
    transferase activity GO:0016740 IEA
    adenylate kinase activity GO:0004017 ISO
    kinase activity GO:0016301 IEA
    ATP binding GO:0005524 IEA
    nucleobase-containing compound kinase activity GO:0019205 ISO
    phosphotransferase activity, phosphate group as acceptor GO:0016776 IEA
Biological Process
    dATP metabolic process GO:0046060 ISO
    AMP metabolic process GO:0046033 ISO
    ATP metabolic process GO:0046034 ISO
    phosphorylation GO:0016310 IEA
    nucleotide phosphorylation GO:0046939 ISO
    ADP biosynthetic process GO:0006172 ISO
    nucleobase-containing compound metabolic process GO:0006139 IEA
Subcellular Localization
    mitochondrial intermembrane space GO:0005758 ISO
    sperm flagellum GO:0036126 IDA
    cytosol GO:0005829 ISO
    extracellular exosome GO:0070062 ISO
    sperm mitochondrial sheath GO:0097226 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Ak2 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ak2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ak2 is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates IEA Reactome





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