Gene description for Ak2
Gene name adenylate kinase 2
Gene symbol Ak2
Other names/aliases Ak-2
D4Ertd220e
Species Mus musculus
 Database cross references - Ak2
ExoCarta ExoCarta_11637
Vesiclepedia VP_11637
Entrez Gene 11637
UniProt Q9WTP6  
 Ak2 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Ak2
Molecular Function
    adenylate kinase activity GO:0004017 IBA
    adenylate kinase activity GO:0004017 IEA
    adenylate kinase activity GO:0004017 ISO
    ATP binding GO:0005524 IEA
    nucleobase-containing compound kinase activity GO:0019205 ISO
Biological Process
    ADP biosynthetic process GO:0006172 IBA
    ADP biosynthetic process GO:0006172 IEA
    ADP biosynthetic process GO:0006172 ISO
    AMP metabolic process GO:0046033 IEA
    AMP metabolic process GO:0046033 ISO
    ATP metabolic process GO:0046034 IEA
    dATP metabolic process GO:0046060 ISO
    nucleoside monophosphate phosphorylation GO:0046940 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial intermembrane space GO:0005758 IEA
    sperm flagellum GO:0036126 IDA
    sperm mitochondrial sheath GO:0097226 IDA
 Experiment description of studies that identified Ak2 in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ak2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ak2 11637
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
2 Aifm1  
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
3 Chchd3  
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml
 Pathways in which Ak2 is involved
PathwayEvidenceSource
Interconversion of nucleotide di- and triphosphates IEA Reactome
Metabolism IEA Reactome
Metabolism of nucleotides IEA Reactome





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