Gene description for Ak4
Gene name adenylate kinase 4
Gene symbol Ak4
Other names/aliases AK 4
Ak-3
Ak-4
Ak3
Ak3l1
D4Ertd274e
Species Mus musculus
 Database cross references - Ak4
ExoCarta ExoCarta_11639
Entrez Gene 11639
UniProt Q9WUR9  
 Ak4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ak4
Molecular Function
    nucleotide binding GO:0000166 IEA
    phosphotransferase activity, phosphate group as acceptor GO:0016776 IEA
    ATP binding GO:0005524 IEA
    nucleoside diphosphate kinase activity GO:0004550 ISO
    kinase activity GO:0016301 IEA
    nucleobase-containing compound kinase activity GO:0019205 IEA
    adenylate kinase activity GO:0004017 IEA
    GTP binding GO:0005525 IEA
    transferase activity GO:0016740 IEA
    nucleoside triphosphate adenylate kinase activity GO:0046899 IEA
Biological Process
    GTP metabolic process GO:0046039 ISO
    phosphorylation GO:0016310 IEA
    nucleoside triphosphate biosynthetic process GO:0009142 ISO
    AMP metabolic process GO:0046033 ISO
    nucleoside diphosphate phosphorylation GO:0006165 ISO
    ATP metabolic process GO:0046034 ISO
    nucleobase-containing compound metabolic process GO:0006139 IEA
Subcellular Localization
    mitochondrial matrix GO:0005759 IDA
    mitochondrion GO:0005739 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Ak4 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ak4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ak4 is involved
No pathways found





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