Gene description for Prdx6
Gene name peroxiredoxin 6
Gene symbol Prdx6
Other names/aliases 1-Cys Prx
1-cysPrx
9430088D19Rik
AA690119
Aop2
Brp-12
CP-3
GPx
Ltw-4
Ltw4
Lvtw-4
NSGPx
ORF06
Prdx5
aiPLA2
Species Mus musculus
 Database cross references - Prdx6
ExoCarta ExoCarta_11758
Vesiclepedia VP_11758
Entrez Gene 11758
UniProt O08709  
 Prdx6 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Prdx6
Molecular Function
    peroxidase activity GO:0004601 IBA
    peroxidase activity GO:0004601 IMP
    glutathione peroxidase activity GO:0004602 ISO
    phospholipase A2 activity GO:0004623 IMP
    phospholipase A2 activity GO:0004623 ISO
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 ISO
    identical protein binding GO:0042802 ISO
    1-acylglycerophosphocholine O-acyltransferase activity GO:0047184 IMP
    1-acylglycerophosphocholine O-acyltransferase activity GO:0047184 ISO
    calcium-dependent phospholipase A2 activity GO:0047498 IEA
    calcium-independent phospholipase A2 activity GO:0047499 IEA
    calcium-independent phospholipase A2 activity GO:0047499 ISO
    peroxiredoxin activity GO:0051920 IEA
Biological Process
    response to reactive oxygen species GO:0000302 IMP
    response to oxidative stress GO:0006979 ISO
    lipid catabolic process GO:0016042 IEA
    bleb assembly GO:0032060 IMP
    hydrogen peroxide catabolic process GO:0042744 ISO
    cell redox homeostasis GO:0045454 IBA
    glycerophospholipid catabolic process GO:0046475 ISO
    positive regulation of mRNA splicing, via spliceosome GO:0048026 ISO
    cellular oxidant detoxification GO:0098869 IEA
    cellular oxidant detoxification GO:0098869 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 HDA
    lysosome GO:0005764 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Prdx6 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Prdx6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP  
Affinity Capture-Western Oryctolagus cuniculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Atxn1  
Proximity Label-MS Mus musculus
4 Ncf2  
Affinity Capture-Western Mus musculus
Co-localization Mus musculus
Reconstituted Complex Mus musculus
5 Usp48  
Affinity Capture-MS Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Cluh  
Affinity Capture-MS Mus musculus
8 MAPT  
Reconstituted Complex Homo sapiens
9 Tfe3  
Affinity Capture-MS Mus musculus
10 Mapt  
Affinity Capture-MS Mus musculus
11 Htt  
Affinity Capture-MS Mus musculus
12 HSD17B10 3028
Affinity Capture-MS Homo sapiens
13 Rtn4ip1  
Co-fractionation Mus musculus
14 Fancd2  
Affinity Capture-MS Mus musculus
15 ARNT 405
Affinity Capture-MS Homo sapiens
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