Gene description for CLC
Gene name Charcot-Leyden crystal galectin
Gene symbol CLC
Other names/aliases GAL10
Gal-10
LGALS10
LGALS10A
LPPL_HUMAN
Species Homo sapiens
 Database cross references - CLC
ExoCarta ExoCarta_1178
Entrez Gene 1178
HGNC 2014
MIM 153310
UniProt Q05315  
 CLC identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CLC
Molecular Function
    carbohydrate binding GO:0030246 IEA
    protein binding GO:0005515 IPI
    cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 IDA
    lysophospholipase activity GO:0004622 IDA
Biological Process
    regulation of T cell anergy GO:0002667 IMP
    T cell apoptotic process GO:0070231 IDA
    multicellular organismal development GO:0007275 TAS
    regulation of T cell cytokine production GO:0002724 IMP
    regulation of activated T cell proliferation GO:0046006 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
 Experiment description of studies that identified CLC in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLC
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLC is involved
No pathways found





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