Experiment description of studies that identified CLC in sEVs

1 Experiment ID 1331 MISEV standards Biophysical techniques ✔ CD9|CD151|CD63|ICAM1|Alix Enriched markers ✘ Negative markers Particle analysis Identified molecule protein Identification method Western blotting PubMed ID 34796683     Organism Homo sapiens Experiment description High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake Authors "Wang T, Wang X, Wang H, Li L, Zhang C, Xiang R, Tan X, Li Z, Jiang C, Zheng L, Xiao L, Yue S." Journal name J Extracell Vesicles Publication year 2021 Sample Breast cancer cells Sample name T-47D Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting

2 Experiment ID 1332 MISEV standards Biophysical techniques ✔ CD9|CD151|CD63|ICAM1|Alix Enriched markers ✘ Negative markers Particle analysis Identified molecule protein Identification method Western blotting PubMed ID 34796683     Organism Homo sapiens Experiment description High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake Authors "Wang T, Wang X, Wang H, Li L, Zhang C, Xiang R, Tan X, Li Z, Jiang C, Zheng L, Xiao L, Yue S." Journal name J Extracell Vesicles Publication year 2021 Sample Breast cancer cells Sample name T-47D Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting

3 Experiment ID 217 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|CD81|CD9|CD63 Enriched markers ✘ Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23844026     Organism Homo sapiens Experiment description Characterization of human thymic exosomes. Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O." Journal name PLoS One Publication year 2013 Sample Thymus Sample name Normal-Thymus Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

Protein-protein interactions for CLC

Protein Interactor ExoCarta ID Identification method PubMed Species 1 CLC 1178 Two-hybrid Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens View the network

Pathways in which CLC is involved

No pathways found