Gene description for Rhob
Gene name ras homolog gene family, member B
Gene symbol Rhob
Other names/aliases AA017882
Species Mus musculus
 Database cross references - Rhob
ExoCarta ExoCarta_11852
Entrez Gene 11852
UniProt P62746  
 Rhob identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Rhob
Molecular Function
    GDP binding GO:0019003 IDA
    GTP binding GO:0005525 TAS
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
Biological Process
    intracellular protein transport GO:0006886 IMP
    small GTPase mediated signal transduction GO:0007264 IEA
    cellular response to ionizing radiation GO:0071479 ISO
    cell differentiation GO:0030154 IEA
    multicellular organismal development GO:0007275 IEA
    protein transport GO:0015031 IEA
    angiogenesis GO:0001525 IEA
    positive regulation of angiogenesis GO:0045766 IMP
    negative regulation of cell cycle GO:0045786 IMP
    transformed cell apoptotic process GO:0006927 IDA
    endosome to lysosome transport GO:0008333 ISO
    transport GO:0006810 IEA
    apoptotic process GO:0006915 IEA
    positive regulation of apoptotic process GO:0043065 ISO
    cellular response to hydrogen peroxide GO:0070301 ISO
    cytokinesis GO:0000910 ISO
    cell adhesion GO:0007155 IDA
Subcellular Localization
    intracellular GO:0005622 IMP
    endosome GO:0005768 IEA
    late endosome GO:0005770 IDA
    cleavage furrow GO:0032154 ISO
    nucleus GO:0005634 IDA
    endosome membrane GO:0010008 ISO
    focal adhesion GO:0005925 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISO
    membrane GO:0016020 ISO
    early endosome GO:0005769 IDA
    plasma membrane GO:0005886 ISO
    cell GO:0005623 IMP
 Experiment description of studies that identified Rhob in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Rhob
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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