Gene description for Atoh1
Gene name atonal homolog 1 (Drosophila)
Gene symbol Atoh1
Other names/aliases Hath1
MATH-1
Math1
bHLHa14
Species Mus musculus
 Database cross references - Atoh1
ExoCarta ExoCarta_11921
Vesiclepedia VP_11921
Entrez Gene 11921
UniProt P48985  
 Atoh1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Atoh1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    chromatin DNA binding GO:0031490 IDA
    sequence-specific DNA binding GO:0043565 IDA
    protein dimerization activity GO:0046983 IEA
    E-box binding GO:0070888 IBA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    neuron migration GO:0001764 IMP
    transcription by RNA polymerase II GO:0006366 IMP
    Notch signaling pathway GO:0007219 IDA
    axon guidance GO:0007411 IMP
    brain development GO:0007420 IMP
    sensory organ development GO:0007423 IBA
    negative regulation of gliogenesis GO:0014014 IGI
    cerebral cortex development GO:0021987 IMP
    cell differentiation GO:0030154 IMP
    neuron differentiation GO:0030182 IMP
    inner ear morphogenesis GO:0042472 IMP
    inner ear auditory receptor cell differentiation GO:0042491 IDA
    inner ear auditory receptor cell differentiation GO:0042491 IDA
    inner ear auditory receptor cell differentiation GO:0042491 IMP
    auditory receptor cell fate specification GO:0042667 IMP
    auditory receptor cell fate determination GO:0042668 IDA
    positive regulation of inner ear auditory receptor cell differentiation GO:0045609 IDA
    regulation of neuron differentiation GO:0045664 IDA
    positive regulation of neuron differentiation GO:0045666 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    neuron fate commitment GO:0048663 IBA
    inner ear development GO:0048839 IMP
    axon development GO:0061564 IBA
    neuroblast migration GO:0097402 IMP
    epithelial cell apoptotic process GO:1904019 IMP
    negative regulation of epithelial cell apoptotic process GO:1904036 IMP
    positive regulation of inner ear receptor cell differentiation GO:2000982 IMP
    positive regulation of inner ear receptor cell differentiation GO:2000982 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Atoh1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Atoh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Runx1t1 12395
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Atoh1 is involved
No pathways found





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