Gene description for Atoh1
Gene name atonal homolog 1 (Drosophila)
Gene symbol Atoh1
Other names/aliases Hath1
MATH-1
Math1
bHLHa14
Species Mus musculus
 Database cross references - Atoh1
ExoCarta ExoCarta_11921
Entrez Gene 11921
UniProt P48985  
 Atoh1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Atoh1
Molecular Function
    DNA binding GO:0003677 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    chromatin DNA binding GO:0031490 IDA
    protein dimerization activity GO:0046983 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    sequence-specific DNA binding GO:0043565 IDA
    protein binding GO:0005515 IPI
Biological Process
    brain development GO:0007420 IMP
    nervous system development GO:0007399 IEA
    positive regulation of inner ear receptor cell differentiation GO:2000982 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of neuron differentiation GO:0045666 IDA
    Notch signaling pathway GO:0007219 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    axon guidance GO:0007411 IMP
    neuron migration GO:0001764 IMP
    auditory receptor cell fate determination GO:0042668 IDA
    auditory receptor cell fate specification GO:0042667 IMP
    positive regulation of auditory receptor cell differentiation GO:0045609 IDA
    multicellular organismal development GO:0007275 IEA
    cell differentiation GO:0030154 IMP
    regulation of neuron differentiation GO:0045664 IDA
    transcription from RNA polymerase II promoter GO:0006366 IDA
    auditory receptor cell differentiation GO:0042491 IMP
    neuron differentiation GO:0030182 IMP
    cerebral cortex development GO:0021987 IMP
    transcription, DNA-templated GO:0006351 IEA
    inner ear development GO:0048839 IMP
    inner ear morphogenesis GO:0042472 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Atoh1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Atoh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atoh1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here