Gene description for Runx1t1
Gene name runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Gene symbol Runx1t1
Other names/aliases Cbfa2t1h
ETO
MTG8
Species Mus musculus
 Database cross references - Runx1t1
ExoCarta ExoCarta_12395
Entrez Gene 12395
UniProt Q61909  
 Runx1t1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Runx1t1
Molecular Function
    DNA binding GO:0003677 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
    transcription corepressor activity GO:0003714 IBA
    metal ion binding GO:0046872 IEA
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IPI
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 IBA
    fat cell differentiation GO:0045444 IDA
    regulation of DNA binding GO:0051101 IDA
    regulation of transcription, DNA-templated GO:0006355 IDA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    nuclear matrix GO:0016363 ISO
 Experiment description of studies that identified Runx1t1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Runx1t1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Runx1t1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here