Gene description for Neurod1
Gene name neurogenic differentiation 1
Gene symbol Neurod1
Other names/aliases BETA2
BHF-1
Neurod
bHLHa3
Species Mus musculus
 Database cross references - Neurod1
ExoCarta ExoCarta_18012
Vesiclepedia VP_18012
Entrez Gene 18012
UniProt Q60867  
 Neurod1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Neurod1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISO
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 IDA
    double-stranded DNA binding GO:0003690 ISO
    DNA-binding transcription factor activity GO:0003700 ISO
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific DNA binding GO:0043565 ISO
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISO
    E-box binding GO:0070888 IBA
    E-box binding GO:0070888 IDA
    E-box binding GO:0070888 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    pancreatic A cell fate commitment GO:0003326 IGI
    pancreatic PP cell fate commitment GO:0003329 IGI
    transcription by RNA polymerase II GO:0006366 IMP
    nucleocytoplasmic transport GO:0006913 IEA
    nucleocytoplasmic transport GO:0006913 ISO
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    sensory organ development GO:0007423 IBA
    response to glucose GO:0009749 ISO
    anterior/posterior pattern specification GO:0009952 IMP
    dentate gyrus development GO:0021542 IGI
    dentate gyrus development GO:0021542 IMP
    cerebellum development GO:0021549 IMP
    signal transduction involved in regulation of gene expression GO:0023019 IDA
    insulin secretion GO:0030073 IEA
    insulin secretion GO:0030073 ISO
    hindbrain development GO:0030902 IMP
    endocrine pancreas development GO:0031018 IMP
    amacrine cell differentiation GO:0035881 IDA
    enteroendocrine cell differentiation GO:0035883 IMP
    glucose homeostasis GO:0042593 IMP
    camera-type eye development GO:0043010 IGI
    positive regulation of apoptotic process GO:0043065 IDA
    cell fate commitment GO:0045165 IGI
    positive regulation of cell differentiation GO:0045597 IDA
    regulation of neuron differentiation GO:0045664 IGI
    positive regulation of neuron differentiation GO:0045666 IDA
    positive regulation of neuron differentiation GO:0045666 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IDA
    embryonic organ morphogenesis GO:0048562 IMP
    inner ear development GO:0048839 IMP
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    positive regulation of DNA-binding transcription factor activity GO:0051091 ISO
    regulation of intestinal epithelial structure maintenance GO:0060730 IDA
    axon development GO:0061564 IBA
    cellular response to glucose stimulus GO:0071333 IEA
    cellular response to glucose stimulus GO:0071333 ISO
    negative regulation of type B pancreatic cell apoptotic process GO:2000675 IMP
    positive regulation of transcription regulatory region DNA binding GO:2000679 ISO
Subcellular Localization
    intracellular anatomical structure GO:0005622 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    RNA polymerase II transcription regulator complex GO:0090575 IEA
    RNA polymerase II transcription regulator complex GO:0090575 ISO
 Experiment description of studies that identified Neurod1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Neurod1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Runx1t1 12395
Two-hybrid Mus musculus
2 Rbl1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
3 Mixl1  
Two-hybrid Mus musculus
4 Rb1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
5 Skull21  
Two-hybrid Mus musculus
6 Nr4a1  
Affinity Capture-Western Mus musculus
7 Neurod1 18012
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
8 Eya1  
Affinity Capture-Western Mus musculus
9 Tcf3  
Two-hybrid Mus musculus
10 Six1  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Neurod1 is involved
No pathways found





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