Gene description for Neurod1
Gene name neurogenic differentiation 1
Gene symbol Neurod1
Other names/aliases BETA2
BHF-1
Neurod
bHLHa3
Species Mus musculus
 Database cross references - Neurod1
ExoCarta ExoCarta_18012
Entrez Gene 18012
UniProt Q60867  
 Neurod1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Neurod1
Molecular Function
    double-stranded DNA binding GO:0003690 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    chromatin binding GO:0003682 IDA
    RNA polymerase II transcription coactivator activity GO:0001105 ISO
    sequence-specific DNA binding GO:0043565 ISO
    RNA polymerase II activating transcription factor binding GO:0001102 ISO
    protein heterodimerization activity GO:0046982 ISO
    transcription coactivator activity GO:0003713 ISO
    protein dimerization activity GO:0046983 IEA
    transcription factor binding GO:0008134 ISO
    DNA binding GO:0003677 IDA
    E-box binding GO:0070888 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of JAK-STAT cascade GO:0046426 IDA
    transcription from RNA polymerase II promoter GO:0006366 IDA
    nervous system development GO:0007399 IEA
    positive regulation of transcription regulatory region DNA binding GO:2000679 ISO
    camera-type eye development GO:0043010 IGI
    positive regulation of neuron differentiation GO:0045666 ISO
    inner ear development GO:0048839 IMP
    negative regulation of type B pancreatic cell apoptotic process GO:2000675 IMP
    nucleocytoplasmic transport GO:0006913 ISO
    pancreatic PP cell fate commitment GO:0003329 IGI
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of cell differentiation GO:0045597 IDA
    response to glucose GO:0009749 ISO
    signal transduction involved in regulation of gene expression GO:0023019 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    regulation of intestinal epithelial structure maintenance GO:0060730 IDA
    enteroendocrine cell differentiation GO:0035883 IMP
    amacrine cell differentiation GO:0035881 IDA
    cell fate commitment GO:0045165 IGI
    cell differentiation GO:0030154 IEA
    endocrine pancreas development GO:0031018 IMP
    nitric oxide mediated signal transduction GO:0007263 ISO
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO
    glucose homeostasis GO:0042593 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    pancreatic A cell fate commitment GO:0003326 IGI
    cerebellum development GO:0021549 IMP
    regulation of cell cycle arrest GO:0071156 IMP
    embryonic organ morphogenesis GO:0048562 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    hindbrain development GO:0030902 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    insulin secretion GO:0030073 ISO
    regulation of neuron differentiation GO:0045664 IGI
    dentate gyrus development GO:0021542 IMP
    multicellular organismal development GO:0007275 IEA
    anterior/posterior pattern specification GO:0009952 IMP
    cellular response to glucose stimulus GO:0071333 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    intracellular GO:0005622 IDA
    RNA polymerase II transcription factor complex GO:0090575 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Neurod1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Neurod1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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