Gene description for B2m
Gene name beta-2 microglobulin
Gene symbol B2m
Other names/aliases Ly-m11
beta2-m
beta2m
Species Mus musculus
 Database cross references - B2m
ExoCarta ExoCarta_12010
Entrez Gene 12010
UniProt P01887  
 B2m identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
Neural stem cells 25242146    
 Gene ontology annotations for B2m
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    glycoprotein binding GO:0001948 ISO
Biological Process
    immune system process GO:0002376 IEA
    response to molecule of bacterial origin GO:0002237 IMP
    positive regulation of T cell mediated cytotoxicity GO:0001916 IMP
    cellular defense response GO:0006968 TAS
    negative regulation of receptor binding GO:1900121 ISO
    T cell differentiation in thymus GO:0033077 IGI
    antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IMP
    protein refolding GO:0042026 IDA
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 IEA
    iron ion homeostasis GO:0055072 IMP
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 ISO
    Golgi apparatus GO:0005794 ISO
    MHC class I protein complex GO:0042612 IEA
    focal adhesion GO:0005925 ISO
    cytoplasm GO:0005737 ISO
    extracellular space GO:0005615 ISO
    membrane GO:0016020 ISO
    extracellular region GO:0005576 IEA
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified B2m in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for B2m
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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