Gene description for Cstb
Gene name cystatin B
Gene symbol Cstb
Other names/aliases AA960480
Stfb
Species Mus musculus
 Database cross references - Cstb
ExoCarta ExoCarta_13014
Entrez Gene 13014
UniProt Q62426  
 Cstb identified in exosomes derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Cstb
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    peptidase inhibitor activity GO:0030414 IEA
    endopeptidase inhibitor activity GO:0004866 ISO
    protease binding GO:0002020 ISO
    cysteine-type endopeptidase inhibitor activity GO:0004869 ISO
Biological Process
    adult locomotory behavior GO:0008344 IMP
    negative regulation of endopeptidase activity GO:0010951 ISO
    negative regulation of peptidase activity GO:0010466 ISO
    negative regulation of proteolysis GO:0045861 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    nucleolus GO:0005730 ISO
    nucleus GO:0005634 ISO
    intracellular GO:0005622 IEA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Cstb in exosomes
1
Experiment ID 14
ISEV standards
EM
EV Biophysical techniques
RAB7|RAB11
EV Cytosolic markers
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
DNM
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Cstb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cstb is involved
No pathways found





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