Gene description for Ctsb
Gene name cathepsin B
Gene symbol Ctsb
Other names/aliases CB
Species Mus musculus
 Database cross references - Ctsb
ExoCarta ExoCarta_13030
Entrez Gene 13030
UniProt P10605  
 Ctsb identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Ctsb
Molecular Function
    hydrolase activity GO:0016787 IEA
    kininogen binding GO:0030984 ISO
    protein self-association GO:0043621 ISO
    cysteine-type peptidase activity GO:0008234 ISO
    peptide binding GO:0042277 ISO
    proteoglycan binding GO:0043394 ISO
    endopeptidase activity GO:0004175 ISO
    peptidase activity GO:0008233 ISO
    cysteine-type endopeptidase activity GO:0004197 ISO
    collagen binding GO:0005518 ISO
    protein complex binding GO:0032403 ISO
Biological Process
    decidualization GO:0046697 IGI
    regulation of catalytic activity GO:0050790 IEA
    collagen catabolic process GO:0030574 ISO
    proteolysis GO:0006508 ISO
    proteolysis involved in cellular protein catabolic process GO:0051603 ISO
    negative regulation of cell death GO:0060548 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    extracellular region GO:0005576 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cell surface GO:0009986 ISO
    lysosome GO:0005764 ISO
    cytoplasm GO:0005737 ISO
    caveola GO:0005901 ISO
    apical plasma membrane GO:0016324 ISO
    sarcolemma GO:0042383 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular space GO:0005615 ISO
    nucleolus GO:0005730 ISO
    external side of plasma membrane GO:0009897 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Ctsb in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ctsb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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