Gene description for Ctsl
Gene name cathepsin L
Gene symbol Ctsl
Other names/aliases 1190035F06Rik
Ctsl1
MEP
fs
nkt
Species Mus musculus
 Database cross references - Ctsl
ExoCarta ExoCarta_13039
Vesiclepedia VP_13039
Entrez Gene 13039
UniProt P06797  
 Ctsl identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ctsl
Molecular Function
    cysteine-type peptidase activity GO:0008234 IEA
    hydrolase activity GO:0016787 IEA
    peptide binding GO:0042277 ISO
    aminopeptidase activity GO:0004177 ISO
    peptidase activity GO:0008233 IEA
    protein binding GO:0005515 IPI
    kininogen binding GO:0030984 ISO
    histone binding GO:0042393 IDA
    cysteine-type carboxypeptidase activity GO:0016807 IDA
    cysteine-type endopeptidase activity GO:0004197 ISO
    protein complex binding GO:0032403 ISO
Biological Process
    regulation of actin cytoskeleton reorganization GO:2000249 IGI
    hair follicle morphogenesis GO:0031069 IMP
    proteolysis GO:0006508 ISO
    negative regulation of keratinocyte proliferation GO:0010839 IMP
    epithelial tube branching involved in lung morphogenesis GO:0060441 IMP
    decidualization GO:0046697 IGI
    protein processing GO:0016485 IMP
    protein autoprocessing GO:0016540 IDA
    cell communication GO:0007154 ISO
    proteolysis involved in cellular protein catabolic process GO:0051603 IBA
    catagen GO:0042637 IMP
Subcellular Localization
    perikaryon GO:0043204 ISO
    extracellular space GO:0005615 IDA
    apical part of cell GO:0045177 ISO
    cytoplasm GO:0005737 ISO
    external side of plasma membrane GO:0009897 ISO
    neuron projection GO:0043005 ISO
    secretory granule GO:0030141 ISO
    vacuole GO:0005773 ISO
    nucleus GO:0005634 IDA
    microvillus GO:0005902 ISO
    nucleolus GO:0005730 IDA
    cytoplasmic vesicle GO:0031410 IDA
    extracellular exosome GO:0070062 ISO
    lysosome GO:0005764 ISO
 Experiment description of studies that identified Ctsl in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ctsl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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