Gene description for Dbnl
Gene name drebrin-like
Gene symbol Dbnl
Other names/aliases Abp1
SH3P7
mAbp1
Species Mus musculus
 Database cross references - Dbnl
ExoCarta ExoCarta_13169
Vesiclepedia VP_13169
Entrez Gene 13169
UniProt Q62418  
 Dbnl identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dbnl
Molecular Function
    actin binding GO:0003779 IDA
    protein domain specific binding GO:0019904 IDA
    protein binding GO:0005515 IPI
    protein C-terminus binding GO:0008022 ISO
    actin filament binding GO:0051015 IDA
Biological Process
    neuron projection morphogenesis GO:0048812 IMP
    actin filament bundle assembly GO:0051017 IDA
    barbed-end actin filament capping GO:0051016 IDA
    actin filament severing GO:0051014 IDA
    receptor-mediated endocytosis GO:0006898 IEA
    synapse assembly GO:0007416 IMP
    endocytosis GO:0006897 IEA
    transport GO:0006810 IEA
    immune system process GO:0002376 IEA
    ruffle assembly GO:0097178 IEA
    Rac protein signal transduction GO:0016601 IDA
    podosome assembly GO:0071800 IMP
Subcellular Localization
    lamellipodium GO:0030027 IDA
    cytoplasmic vesicle GO:0031410 IEA
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 IEA
    cytoskeleton GO:0005856 IEA
    ruffle GO:0001726 IDA
    cell cortex GO:0005938 IDA
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 IDA
    postsynaptic density GO:0014069 ISO
    synapse GO:0045202 IEA
    intracellular GO:0005622 IEA
    dendrite GO:0030425 ISO
    cell projection GO:0042995 IEA
    cell junction GO:0030054 IEA
    podosome GO:0002102 IDA
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified Dbnl in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dbnl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dbnl is involved
PathwayEvidenceSource
Caspase-mediated cleavage of cytoskeletal proteins IEA Reactome





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