Gene description for Tpm3
Gene name tropomyosin 3, gamma
Gene symbol Tpm3
Other names/aliases TM30nm
TMnm
Tm5NM
Tpm-5
Tpm5
Trop-5
gamma-TM
hTM30nm
hTMnm
Species Mus musculus
 Database cross references - Tpm3
ExoCarta ExoCarta_59069
Entrez Gene 59069
UniProt P21107  
 Tpm3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tpm3
Molecular Function
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IEA
Subcellular Localization
    growth cone GO:0030426 IDA
    cortical cytoskeleton GO:0030863 IDA
    extracellular exosome GO:0070062 ISO
    stress fiber GO:0001725 ISO
    neuron projection GO:0043005 IDA
    cleavage furrow GO:0032154 IDA
    cytoskeleton GO:0005856 IEA
    filamentous actin GO:0031941 IDA
    cytoplasm GO:0005737 IDA
    podosome GO:0002102 IDA
 Experiment description of studies that identified Tpm3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tpm3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tpm3 is involved
No pathways found





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