Gene description for Dtnb
Gene name dystrobrevin, beta
Gene symbol Dtnb
Other names/aliases -
Species Mus musculus
 Database cross references - Dtnb
ExoCarta ExoCarta_13528
Vesiclepedia VP_13528
Entrez Gene 13528
UniProt O70585  
 Dtnb identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dtnb
Molecular Function
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    phosphatase binding GO:0019902 ISO
Biological Process
    neuron differentiation GO:0030182 ISO
    synaptic signaling GO:0099536 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IBA
    basal plasma membrane GO:0009925 IEA
    postsynaptic density GO:0014069 ISO
    postsynaptic density GO:0014069 ISS
    dendrite GO:0030425 IEA
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    inhibitory synapse GO:0060077 IDA
    postsynapse GO:0098794 IDA
    GABA-ergic synapse GO:0098982 IDA
 Experiment description of studies that identified Dtnb in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dtnb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dtna  
Co-fractionation Mus musculus
2 Sntb2 20650
Reconstituted Complex Mus musculus
3 Sntb1  
Reconstituted Complex Mus musculus
4 Krt40  
Co-fractionation Mus musculus
5 Sntg1  
Reconstituted Complex Mus musculus
6 Sntg2  
Reconstituted Complex Mus musculus
7 Zbtb9  
Co-fractionation Mus musculus
8 Snta1  
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Dtnb is involved
No pathways found





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