Gene description for CPA1
Gene name carboxypeptidase A1 (pancreatic)
Gene symbol CPA1
Other names/aliases CPA
Species Homo sapiens
 Database cross references - CPA1
ExoCarta ExoCarta_1357
Vesiclepedia VP_1357
Entrez Gene 1357
HGNC 2296
MIM 114850
UniProt P15085  
 CPA1 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CPA1
Molecular Function
    metallocarboxypeptidase activity GO:0004181 IBA
    metallocarboxypeptidase activity GO:0004181 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IBA
    leukotriene metabolic process GO:0006691 ISS
    response to cadmium ion GO:0046686 IEA
    proteolysis involved in protein catabolic process GO:0051603 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CPA1 in sEVs
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CPA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARRB1 408
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CPA1 is involved
No pathways found





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