Gene description for Aimp1
Gene name aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Gene symbol Aimp1
Other names/aliases 9830137A06Rik
AIMP1/p43
EMAPII
Emap2
Scye1
p43
Species Mus musculus
 Database cross references - Aimp1
ExoCarta ExoCarta_13722
Vesiclepedia VP_13722
Entrez Gene 13722
 Aimp1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aimp1
Molecular Function
    tRNA binding GO:0000049 ISO
    tRNA binding GO:0000049 ISS
    cytokine activity GO:0005125 IDA
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    GTPase binding GO:0051020 ISO
Biological Process
    angiogenesis GO:0001525 IEA
    negative regulation of endothelial cell proliferation GO:0001937 ISO
    negative regulation of endothelial cell proliferation GO:0001937 ISS
    translation GO:0006412 IEA
    apoptotic process GO:0006915 IEA
    inflammatory response GO:0006954 IEA
    signal transduction GO:0007165 IEA
    cell-cell signaling GO:0007267 ISO
    leukocyte migration GO:0050900 IDA
    leukocyte migration GO:0050900 ISO
    positive regulation of glucagon secretion GO:0070094 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 IEA
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IEA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cell surface GO:0009986 ISO
    cell surface GO:0009986 ISS
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 IDA
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 ISO
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 ISS
 Experiment description of studies that identified Aimp1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aimp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Rars 104458
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Aimp1 is involved
No pathways found





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