Gene description for Rars
Gene name arginyl-tRNA synthetase
Gene symbol Rars
Other names/aliases 2610011N19Rik
2610037E21Rik
AL033339
AW985894
Species Mus musculus
 Database cross references - Rars
ExoCarta ExoCarta_104458
Vesiclepedia VP_104458
Entrez Gene 104458
UniProt Q9D0I9  
 Rars identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rars
Molecular Function
    ligase activity GO:0016874 IEA
    arginine binding GO:0034618 ISO
    nucleotide binding GO:0000166 IEA
    aminoacyl-tRNA ligase activity GO:0004812 IEA
    tRNA binding GO:0000049 ISO
    ATP binding GO:0005524 ISO
    arginine-tRNA ligase activity GO:0004814 ISO
Biological Process
    translation GO:0006412 IEA
    tRNA aminoacylation for protein translation GO:0006418 IEA
    arginyl-tRNA aminoacylation GO:0006420 ISO
Subcellular Localization
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 ISO
    membrane GO:0016020 ISO
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Rars in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rars
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rars is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here