Gene description for Kars
Gene name lysyl-tRNA synthetase
Gene symbol Kars
Other names/aliases AA589550
AL024334
AL033315
AL033367
D8Ertd698e
D8Wsu108e
LysRS
mKIAA0070
Species Mus musculus
 Database cross references - Kars
ExoCarta ExoCarta_85305
Vesiclepedia VP_85305
Entrez Gene 85305
UniProt Q99MN1  
 Kars identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Kars
Molecular Function
    amino acid binding GO:0016597 ISO
    tRNA binding GO:0000049 ISO
    lysine-tRNA ligase activity GO:0004824 ISO
    nucleic acid binding GO:0003676 IEA
    aminoacyl-tRNA ligase activity GO:0004812 IEA
    ATP binding GO:0005524 ISO
    nucleotide binding GO:0000166 IEA
    metal ion binding GO:0046872 IEA
    ligase activity GO:0016874 IEA
Biological Process
    tRNA aminoacylation for protein translation GO:0006418 IEA
    diadenosine tetraphosphate biosynthetic process GO:0015966 ISO
    lysyl-tRNA aminoacylation GO:0006430 ISO
    translation GO:0006412 IEA
Subcellular Localization
    microtubule cytoskeleton GO:0015630 ISO
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Kars in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Kars
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Kars is involved
No pathways found





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