Gene description for Lars
Gene name leucyl-tRNA synthetase
Gene symbol Lars
Other names/aliases 2310045K21Rik
Species Mus musculus
 Database cross references - Lars
ExoCarta ExoCarta_107045
Entrez Gene 107045
UniProt Q8BMJ2  
 Lars identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Lars
Molecular Function
    aminoacyl-tRNA editing activity GO:0002161 IEA
    aminoacyl-tRNA ligase activity GO:0004812 IEA
    leucine-tRNA ligase activity GO:0004823 IBA
    ATP binding GO:0005524 IEA
    nucleotide binding GO:0000166 IEA
    ligase activity GO:0016874 IEA
Biological Process
    tRNA aminoacylation for protein translation GO:0006418 IEA
    leucyl-tRNA aminoacylation GO:0006429 IBA
    translation GO:0006412 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
 Experiment description of studies that identified Lars in exosomes
Experiment ID 188
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Lars
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lars is involved
No pathways found

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