Gene description for Epha2
Gene name Eph receptor A2
Gene symbol Epha2
Other names/aliases AW545284
Eck
Myk2
Sek-2
Sek2
Species Mus musculus
 Database cross references - Epha2
ExoCarta ExoCarta_13836
Vesiclepedia VP_13836
Entrez Gene 13836
UniProt Q03145  
 Epha2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Epha2
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 ISO
    transmembrane receptor protein tyrosine kinase activity GO:0004714 ISS
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    growth factor binding GO:0019838 IEA
    growth factor binding GO:0019838 ISO
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    molecular function activator activity GO:0140677 ISO
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    skeletal system development GO:0001501 IMP
    blood vessel development GO:0001568 IMP
    vasculogenesis GO:0001570 IMP
    osteoblast differentiation GO:0001649 IMP
    negative regulation of cytokine production GO:0001818 IMP
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 IMP
    chromatin remodeling GO:0006338 IEA
    inflammatory response GO:0006954 IMP
    cell adhesion GO:0007155 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 ISO
    regulation of lamellipodium assembly GO:0010591 ISO
    regulation of lamellipodium assembly GO:0010591 ISS
    notochord formation GO:0014028 IGI
    notochord formation GO:0014028 IMP
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    negative regulation of angiogenesis GO:0016525 IMP
    neural tube development GO:0021915 IMP
    neuron differentiation GO:0030182 IDA
    neuron differentiation GO:0030182 IMP
    keratinocyte differentiation GO:0030216 IEA
    keratinocyte differentiation GO:0030216 ISO
    osteoclast differentiation GO:0030316 IDA
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    negative regulation of chemokine production GO:0032682 IMP
    mammary gland epithelial cell proliferation GO:0033598 IMP
    regulation of cell adhesion mediated by integrin GO:0033628 ISO
    regulation of cell adhesion mediated by integrin GO:0033628 ISS
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    post-anal tail morphogenesis GO:0036342 IMP
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    regulation of blood vessel endothelial cell migration GO:0043535 IDA
    regulation of angiogenesis GO:0045765 IDA
    cAMP metabolic process GO:0046058 ISO
    cAMP metabolic process GO:0046058 ISS
    bone remodeling GO:0046849 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IDA
    ephrin receptor signaling pathway GO:0048013 IMP
    ephrin receptor signaling pathway GO:0048013 ISO
    axial mesoderm formation GO:0048320 IMP
    blood vessel morphogenesis GO:0048514 IMP
    notochord morphogenesis GO:0048570 IMP
    cell motility GO:0048870 ISO
    cell motility GO:0048870 ISS
    defense response to Gram-positive bacterium GO:0050830 IMP
    notochord cell development GO:0060035 IMP
    cell chemotaxis GO:0060326 ISO
    cell chemotaxis GO:0060326 ISS
    branching involved in mammary gland duct morphogenesis GO:0060444 IMP
    lens fiber cell morphogenesis GO:0070309 IDA
    regulation of ERK1 and ERK2 cascade GO:0070372 IEA
    regulation of ERK1 and ERK2 cascade GO:0070372 ISO
    response to growth factor GO:0070848 ISO
    response to growth factor GO:0070848 ISS
    protein localization to plasma membrane GO:0072659 IEA
    protein localization to plasma membrane GO:0072659 ISO
    activation of GTPase activity GO:0090630 ISO
    activation of GTPase activity GO:0090630 ISS
    negative regulation of lymphangiogenesis GO:1901491 IMP
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
    positive regulation of protein localization to plasma membrane GO:1903078 ISS
    positive regulation of bicellular tight junction assembly GO:1903348 IEA
    positive regulation of bicellular tight junction assembly GO:1903348 ISO
    pericyte cell differentiation GO:1904238 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISS
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    lamellipodium GO:0030027 ISO
    lamellipodium GO:0030027 ISS
    leading edge membrane GO:0031256 ISO
    leading edge membrane GO:0031256 ISS
    lamellipodium membrane GO:0031258 IEA
    ruffle membrane GO:0032587 IEA
    receptor complex GO:0043235 IBA
    tight junction GO:0070160 IEA
    tight junction GO:0070160 ISO
 Experiment description of studies that identified Epha2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Epha2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tiam1 21844
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Nphs2  
Affinity Capture-MS Mus musculus
3 Nphp4  
Affinity Capture-MS Mus musculus
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