Gene description for Tiam1
Gene name T cell lymphoma invasion and metastasis 1
Gene symbol Tiam1
Other names/aliases AI847750
D16Ium10
D16Ium10e
Species Mus musculus
 Database cross references - Tiam1
ExoCarta ExoCarta_21844
Entrez Gene 21844
 Tiam1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tiam1
Molecular Function
    phospholipid binding GO:0005543 IDA
    receptor signaling protein activity GO:0005057 IEA
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    lipid binding GO:0008289 IEA
    receptor tyrosine kinase binding GO:0030971 IPI
    Rac guanyl-nucleotide exchange factor activity GO:0030676 ISO
    protein binding GO:0005515 IPI
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    ephrin receptor binding GO:0046875 IPI
Biological Process
    cell-matrix adhesion GO:0007160 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IDA
    positive regulation of axonogenesis GO:0050772 IMP
    ephrin receptor signaling pathway GO:0048013 IDA
    small GTPase mediated signal transduction GO:0007264 IDA
    regulation of Rho protein signal transduction GO:0035023 IEA
    regulation of GTPase activity GO:0043087 IDA
    cell migration GO:0016477 ISO
    positive regulation of neuron projection development GO:0010976 IDA
    intracellular signal transduction GO:0035556 IEA
    Rac protein signal transduction GO:0016601 ISO
    signal transduction GO:0007165 IEA
Subcellular Localization
    cell junction GO:0030054 IEA
    cell-cell junction GO:0005911 ISO
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISO
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IEA
    intracellular GO:0005622 IDA
    cell-cell contact zone GO:0044291 ISO
 Experiment description of studies that identified Tiam1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tiam1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tiam1 is involved
No pathways found





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