Gene description for Tiam1
Gene name T cell lymphoma invasion and metastasis 1
Gene symbol Tiam1
Other names/aliases AI847750
D16Ium10
D16Ium10e
Species Mus musculus
 Database cross references - Tiam1
ExoCarta ExoCarta_21844
Vesiclepedia VP_21844
Entrez Gene 21844
 Tiam1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tiam1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 IMP
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IDA
    microtubule binding GO:0008017 IDA
    microtubule binding GO:0008017 ISO
    kinase binding GO:0019900 ISO
    receptor tyrosine kinase binding GO:0030971 IPI
    receptor tyrosine kinase binding GO:0030971 ISO
    ephrin receptor binding GO:0046875 IPI
Biological Process
    cardiac muscle hypertrophy GO:0003300 ISO
    cell-matrix adhesion GO:0007160 ISO
    cell-matrix adhesion GO:0007160 ISS
    small GTPase-mediated signal transduction GO:0007264 IBA
    small GTPase-mediated signal transduction GO:0007264 IDA
    positive regulation of cell population proliferation GO:0008284 ISO
    regulation of epithelial to mesenchymal transition GO:0010717 ISO
    positive regulation of neuron projection development GO:0010976 IDA
    positive regulation of neuron projection development GO:0010976 ISO
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    Rac protein signal transduction GO:0016601 ISO
    Rac protein signal transduction GO:0016601 ISS
    positive regulation of cell migration GO:0030335 ISO
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IDA
    positive regulation of protein binding GO:0032092 ISO
    regulation of GTPase activity GO:0043087 IDA
    ephrin receptor signaling pathway GO:0048013 IDA
    positive regulation of axonogenesis GO:0050772 IBA
    positive regulation of axonogenesis GO:0050772 IMP
    positive regulation of axonogenesis GO:0050772 ISO
    positive regulation of dendritic spine morphogenesis GO:0061003 ISO
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 ISO
    protein-containing complex assembly GO:0065003 ISO
    regulation of ERK1 and ERK2 cascade GO:0070372 ISO
    protein localization to membrane GO:0072657 ISO
    activation of GTPase activity GO:0090630 IMP
    activation of GTPase activity GO:0090630 ISO
    NMDA selective glutamate receptor signaling pathway GO:0098989 ISO
    regulation of postsynapse organization GO:0099175 ISO
    positive regulation of Schwann cell chemotaxis GO:1904268 ISO
    regulation of dopaminergic neuron differentiation GO:1904338 IMP
    regulation of modification of postsynaptic actin cytoskeleton GO:1905274 ISO
    neuron projection extension GO:1990138 ISO
    regulation of non-canonical Wnt signaling pathway GO:2000050 IGI
Subcellular Localization
    pericentriolar material GO:0000242 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    microtubule GO:0005874 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 ISO
    cell-cell junction GO:0005911 ISS
    postsynaptic density GO:0014069 ISO
    ruffle membrane GO:0032587 ISO
    somatodendritic compartment GO:0036477 ISO
    neuronal cell body GO:0043025 ISO
    dendritic spine GO:0043197 ISO
    cell-cell contact zone GO:0044291 ISO
    cell-cell contact zone GO:0044291 ISS
    axonal growth cone GO:0044295 ISO
    main axon GO:0044304 ISO
    synapse GO:0045202 IBA
    kinocilium GO:0060091 IDA
    glutamatergic synapse GO:0098978 ISO
    extrinsic component of postsynaptic density membrane GO:0099147 ISO
 Experiment description of studies that identified Tiam1 in sEVs
1
Experiment ID 15
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tiam1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ephb1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 ITSN1 6453
Two-hybrid Homo sapiens
3 Epha2 13836
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Tiam1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here