Gene description for KBTBD3
Gene name kelch repeat and BTB (POZ) domain containing 3
Gene symbol KBTBD3
Other names/aliases BKLHD3
Species Homo sapiens
 Database cross references - KBTBD3
ExoCarta ExoCarta_143879
Vesiclepedia VP_143879
Entrez Gene 143879
HGNC 22934
UniProt Q8NAB2  
 KBTBD3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KBTBD3
Molecular Function
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IBA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    Cul3-RING ubiquitin ligase complex GO:0031463 IBA
 Experiment description of studies that identified KBTBD3 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KBTBD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MYCN  
Affinity Capture-MS Homo sapiens
2 MYC  
Affinity Capture-MS Homo sapiens
3 MME 4311
Affinity Capture-MS Homo sapiens
4 ANLN 54443
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KBTBD3 is involved
No pathways found





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