Gene description for IL34
Gene name interleukin 34
Gene symbol IL34
Other names/aliases C16orf77
IL-34
Species Homo sapiens
 Database cross references - IL34
ExoCarta ExoCarta_146433
Entrez Gene 146433
HGNC 28529
MIM 612081
UniProt Q6ZMJ4  
 IL34 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for IL34
Molecular Function
    cytokine activity GO:0005125 IEA
    macrophage colony-stimulating factor receptor binding GO:0005157 IDA
    growth factor activity GO:0008083 IEA
Biological Process
    innate immune response GO:0045087 IEA
    inflammatory response GO:0006954 IEA
    positive regulation of protein phosphorylation GO:0001934 IDA
    positive regulation of macrophage differentiation GO:0045651 IDA
    positive regulation of monocyte differentiation GO:0045657 IDA
    positive regulation of cell proliferation GO:0008284 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified IL34 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for IL34
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IL34 is involved
No pathways found





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