Gene description for Gpc1
Gene name glypican 1
Gene symbol Gpc1
Other names/aliases AI462976
Species Mus musculus
 Database cross references - Gpc1
ExoCarta ExoCarta_14733
Entrez Gene 14733
UniProt Q9QZF2  
 Gpc1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Gpc1
Molecular Function
    laminin binding GO:0043236 IDA
    fibroblast growth factor binding GO:0017134 IDA
    heparan sulfate proteoglycan binding GO:0043395 IEA
    collagen V binding GO:0070052 ISO
    copper ion binding GO:0005507 ISO
Biological Process
    Schwann cell differentiation GO:0014037 ISO
    myelin assembly GO:0032288 ISO
    negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 IDA
    heparan sulfate proteoglycan catabolic process GO:0030200 ISO
Subcellular Localization
    anchored component of membrane GO:0031225 IEA
    endosome GO:0005768 IEA
    neuronal cell body GO:0043025 ISO
    membrane raft GO:0045121 ISO
    proteinaceous extracellular matrix GO:0005578 IDA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IEA
    extracellular region GO:0005576 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Gpc1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Gpc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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