Gene description for Pecam1
Gene name platelet/endothelial cell adhesion molecule 1
Gene symbol Pecam1
Other names/aliases C85791
Cd31
PECAM-1
Pecam
Species Mus musculus
 Database cross references - Pecam1
ExoCarta ExoCarta_18613
Vesiclepedia VP_18613
Entrez Gene 18613
UniProt Q08481  
 Pecam1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pecam1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    negative regulation of GTPase activity GO:0034260 ISO
    Rho protein signal transduction GO:0007266 IMP
    phagocytosis GO:0006909 ISO
    positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IDA
    negative regulation of actin filament polymerization GO:0030837 ISO
    regulation of cell migration GO:0030334 IMP
    negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 ISO
    diapedesis GO:0050904 ISO
    wound healing GO:0042060 IMP
    positive regulation of leukocyte migration GO:0002687 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    intracellular GO:0005622 IMP
    cell periphery GO:0071944 IDA
    extracellular exosome GO:0070062 ISO
    cell surface GO:0009986 ISO
    extracellular space GO:0005615 ISO
    membrane GO:0016020 IDA
    cell junction GO:0030054 IEA
    integral component of membrane GO:0016021 IEA
    smooth muscle contractile fiber GO:0030485 IDA
    external side of plasma membrane GO:0009897 IDA
    membrane raft GO:0045121 IDA
 Experiment description of studies that identified Pecam1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pecam1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pecam1 is involved
No pathways found





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