Gene description for ATP8B3
Gene name ATPase, aminophospholipid transporter, class I, type 8B, member 3
Gene symbol ATP8B3
Other names/aliases ATPIK
Species Homo sapiens
 Database cross references - ATP8B3
ExoCarta ExoCarta_148229
Vesiclepedia VP_148229
Entrez Gene 148229
HGNC 13535
MIM 605866
UniProt O60423  
 ATP8B3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ATP8B3
Molecular Function
    magnesium ion binding GO:0000287 IEA
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    phosphatidylserine floppase activity GO:0090556 IEA
    ATPase-coupled intramembrane lipid transporter activity GO:0140326 IBA
Biological Process
    Golgi organization GO:0007030 IBA
    binding of sperm to zona pellucida GO:0007339 IEA
    phospholipid translocation GO:0045332 IBA
    establishment of localization in cell GO:0051649 IEA
Subcellular Localization
    acrosomal membrane GO:0002080 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    trans-Golgi network GO:0005802 IBA
    plasma membrane GO:0005886 IBA
    membrane GO:0016020 NAS
    phospholipid-translocating ATPase complex GO:1990531 NAS
 Experiment description of studies that identified ATP8B3 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ATP8B3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APEX1 328
Affinity Capture-RNA Homo sapiens
2 PARK2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATP8B3 is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Ion transport by P-type ATPases TAS Reactome
Transport of small molecules TAS Reactome





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