Gene description for Ptpn6
Gene name	protein tyrosine phosphatase, non-receptor type 6
Gene symbol	Ptpn6
Other names/aliases	70Z-SHP Hcph PTPTY-42 Ptp1C SH-PTP1 SHP-1 hcp me
Species	Mus musculus
Database cross references - Ptpn6
ExoCarta	ExoCarta_15170
Entrez Gene	15170
UniProt	P29351
Ptpn6 identified in exosomes derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for Ptpn6

Molecular Function     transmembrane receptor protein tyrosine phosphatase activity GO:0005001 ISO     SH3 domain binding GO:0017124 IDA     phosphoprotein phosphatase activity GO:0004721 IEA     phosphatase activity GO:0016791 IEA     hydrolase activity GO:0016787 IEA     protein kinase binding GO:0019901 ISO     SH2 domain binding GO:0042169 IDA     protein tyrosine phosphatase activity GO:0004725 IDA     protein binding GO:0005515 IPI     natural killer cell lectin-like receptor binding GO:0046703 ISO     phosphotyrosine binding GO:0001784 IPI Biological Process     cytokine-mediated signaling pathway GO:0019221 TAS     regulation of B cell differentiation GO:0045577 IMP     negative regulation of MAP kinase activity GO:0043407 IMP     peptidyl-tyrosine dephosphorylation GO:0035335 ISO     negative regulation of B cell receptor signaling pathway GO:0050859 IGI     regulation of G1/S transition of mitotic cell cycle GO:2000045 ISO     protein dephosphorylation GO:0006470 ISO     cell proliferation GO:0008283 ISO     abortive mitotic cell cycle GO:0033277 IMP     hematopoietic progenitor cell differentiation GO:0002244 IMP     regulation of ERK1 and ERK2 cascade GO:0070372 ISO     natural killer cell mediated cytotoxicity GO:0042267 IMP     peptidyl-tyrosine phosphorylation GO:0018108 ISO     negative regulation of T cell receptor signaling pathway GO:0050860 IMP     positive regulation of cell proliferation GO:0008284 ISO     positive regulation of cell adhesion mediated by integrin GO:0033630 IMP     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISO     megakaryocyte development GO:0035855 IMP     dephosphorylation GO:0016311 IEA     platelet formation GO:0030220 IGI     negative regulation of T cell proliferation GO:0042130 IMP     negative regulation of MAPK cascade GO:0043409 IMP     regulation of release of sequestered calcium ion into cytosol GO:0051279 IGI     negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0002924 IMP     platelet aggregation GO:0070527 IMP     signal transduction GO:0007165 ISO     intracellular signal transduction GO:0035556 IDA     cell differentiation GO:0030154 ISO     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 ISO     B cell receptor signaling pathway GO:0050853 IMP Subcellular Localization     cytoplasm GO:0005737 TAS     nucleus GO:0005634 ISO     intracellular GO:0005622 IDA     extracellular exosome GO:0070062 ISO     nucleolus GO:0005730 ISO     alpha-beta T cell receptor complex GO:0042105 IDA     cell-cell junction GO:0005911 IDA