Gene description for Hells
Gene name helicase, lymphoid specific
Gene symbol Hells
Other names/aliases AI323785
E130115I21Rik
LSH
Lysh
PASG
YFK8
Species Mus musculus
 Database cross references - Hells
ExoCarta ExoCarta_15201
Vesiclepedia VP_15201
Entrez Gene 15201
UniProt Q60848  
 Hells identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hells
Molecular Function
    ATP binding GO:0005524 IEA
    helicase activity GO:0004386 IEA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
    nucleotide binding GO:0000166 IEA
    hydrolase activity GO:0016787 IEA
    chromatin binding GO:0003682 IDA
Biological Process
    maintenance of DNA methylation GO:0010216 IMP
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    multicellular organismal development GO:0007275 IMP
    cell cycle GO:0007049 IEA
    cell division GO:0051301 IEA
    urogenital system development GO:0001655 IMP
    chromatin silencing GO:0006342 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    mitotic nuclear division GO:0007067 IEA
    DNA methylation GO:0006306 IMP
    lymphocyte differentiation GO:0030098 TAS
    methylation-dependent chromatin silencing GO:0006346 IMP
    pericentric heterochromatin assembly GO:0031508 IMP
Subcellular Localization
    pericentric heterochromatin GO:0005721 IDA
    nucleus GO:0005634 IDA
    chromosome, centromeric region GO:0000775 IDA
 Experiment description of studies that identified Hells in exosomes
1
Experiment ID 15
MISEV standards
EM
EV Biophysical techniques
CD63
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hells
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hells is involved
No pathways found





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