Gene description for Hexa
Gene name hexosaminidase A
Gene symbol Hexa
Other names/aliases Hex-1
Species Mus musculus
 Database cross references - Hexa
ExoCarta ExoCarta_15211
Vesiclepedia VP_15211
Entrez Gene 15211
UniProt P29416  
 Hexa identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Hexa
Molecular Function
    beta-N-acetylhexosaminidase activity GO:0004563 IBA
    beta-N-acetylhexosaminidase activity GO:0004563 IDA
    beta-N-acetylhexosaminidase activity GO:0004563 IGI
    beta-N-acetylhexosaminidase activity GO:0004563 IMP
    beta-N-acetylhexosaminidase activity GO:0004563 ISO
    acetylglucosaminyltransferase activity GO:0008375 IEA
    acetylglucosaminyltransferase activity GO:0008375 ISO
    beta-N-acetylglucosaminidase activity GO:0016231 IEA
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    skeletal system development GO:0001501 IGI
    carbohydrate metabolic process GO:0005975 IEA
    glycosaminoglycan biosynthetic process GO:0006024 IEA
    glycosaminoglycan biosynthetic process GO:0006024 ISO
    N-glycan processing GO:0006491 IBA
    ganglioside catabolic process GO:0006689 IBA
    ganglioside catabolic process GO:0006689 IMP
    ganglioside catabolic process GO:0006689 ISO
    ganglioside catabolic process GO:0006689 ISS
    lysosome organization GO:0007040 IGI
    lysosome organization GO:0007040 IMP
    sensory perception of sound GO:0007605 IGI
    locomotory behavior GO:0007626 IGI
    adult walking behavior GO:0007628 IMP
    lipid storage GO:0019915 IMP
    sexual reproduction GO:0019953 IMP
    glycosaminoglycan metabolic process GO:0030203 IBA
    glycosaminoglycan metabolic process GO:0030203 IGI
    glycosaminoglycan metabolic process GO:0030203 IMP
    glycosaminoglycan metabolic process GO:0030203 ISO
    dermatan sulfate catabolic process GO:0030209 IGI
    hyaluronan catabolic process GO:0030214 IMP
    myelination GO:0042552 IGI
    cell morphogenesis involved in neuron differentiation GO:0048667 IMP
    neuromuscular process controlling posture GO:0050884 IMP
    neuromuscular process controlling balance GO:0050885 IGI
    maintenance of location in cell GO:0051651 IMP
Subcellular Localization
    lysosome GO:0005764 IBA
    lysosome GO:0005764 IDA
    lysosome GO:0005764 IDA
    lysosome GO:0005764 IMP
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    azurophil granule GO:0042582 IEA
    azurophil granule GO:0042582 ISO
    lysosomal lumen GO:0043202 NAS
    intracellular membrane-bounded organelle GO:0043231 ISO
    beta-N-acetylhexosaminidase complex GO:1905379 ISO
    beta-N-acetylhexosaminidase complex GO:1905379 ISS
 Experiment description of studies that identified Hexa in sEVs
1
Experiment ID 1101
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1102
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F10
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 1103
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for Hexa
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmx3  
Co-fractionation Mus musculus
2 Fkbp9  
Co-fractionation Mus musculus
3 Siae  
Co-fractionation Mus musculus
4 BC005624  
Co-fractionation Mus musculus
5 Uba6 231380
Co-fractionation Mus musculus
6 Nceh1  
Co-fractionation Mus musculus
7 Atg5  
Affinity Capture-RNA Mus musculus
8 Wdr61  
Co-fractionation Mus musculus
9 Sumf1  
Co-fractionation Mus musculus
10 P4htm  
Co-fractionation Mus musculus
11 Iqcb1  
Affinity Capture-MS Mus musculus
12 Fut11  
Co-fractionation Mus musculus
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