Gene description for CYP1B1
Gene name cytochrome P450, family 1, subfamily B, polypeptide 1
Gene symbol CYP1B1
Other names/aliases CP1B
CYPIB1
GLC3A
P4501B1
Species Homo sapiens
 Database cross references - CYP1B1
ExoCarta ExoCarta_1545
Vesiclepedia VP_1545
Entrez Gene 1545
HGNC 2597
MIM 601771
UniProt Q16678  
 CYP1B1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CYP1B1
Molecular Function
    monooxygenase activity GO:0004497 IBA
    monooxygenase activity GO:0004497 IDA
    monooxygenase activity GO:0004497 TAS
    iron ion binding GO:0005506 IEA
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 TAS
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IDA
    heme binding GO:0020037 IDA
    estrogen 16-alpha-hydroxylase activity GO:0101020 IDA
    hydroperoxy icosatetraenoate dehydratase activity GO:0106256 IEA
Biological Process
    angiogenesis GO:0001525 IEA
    trabecular meshwork development GO:0002930 ISS
    DNA modification GO:0006304 IEA
    xenobiotic metabolic process GO:0006805 IDA
    nitric oxide biosynthetic process GO:0006809 ISS
    cell adhesion GO:0007155 ISS
    response to nutrient GO:0007584 IEA
    steroid metabolic process GO:0008202 IDA
    estrogen metabolic process GO:0008210 IDA
    negative regulation of cell population proliferation GO:0008285 ISS
    male gonad development GO:0008584 IEA
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISS
    toxin metabolic process GO:0009404 IEA
    positive regulation of vascular endothelial growth factor production GO:0010575 ISS
    positive regulation of smooth muscle cell migration GO:0014911 IEA
    sterol metabolic process GO:0016125 TAS
    arachidonate metabolic process GO:0019369 IDA
    epoxygenase P450 pathway GO:0019373 TAS
    collagen fibril organization GO:0030199 ISS
    adrenal gland development GO:0030325 IEA
    negative regulation of cell migration GO:0030336 ISS
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS
    response to follicle-stimulating hormone GO:0032354 IEA
    response to estradiol GO:0032355 IEA
    negative regulation of cell adhesion mediated by integrin GO:0033629 ISS
    benzene-containing compound metabolic process GO:0042537 IEA
    retinol metabolic process GO:0042572 IDA
    retinol metabolic process GO:0042572 IEA
    retinal metabolic process GO:0042574 IDA
    positive regulation of apoptotic process GO:0043065 ISS
    blood vessel endothelial cell migration GO:0043534 IEA
    endothelial cell migration GO:0043542 ISS
    estrous cycle GO:0044849 IEA
    positive regulation of translation GO:0045727 IEA
    positive regulation of angiogenesis GO:0045766 ISS
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 ISS
    membrane lipid catabolic process GO:0046466 ISS
    response to arsenic-containing substance GO:0046685 IEA
    blood vessel morphogenesis GO:0048514 ISS
    retinal blood vessel morphogenesis GO:0061304 ISS
    ganglion development GO:0061548 IEA
    cellular response to hydrogen peroxide GO:0070301 ISS
    cellular response to cAMP GO:0071320 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to luteinizing hormone stimulus GO:0071373 IEA
    cellular response to cortisol stimulus GO:0071387 IEA
    cellular response to progesterone stimulus GO:0071393 IEA
    cellular response to organic cyclic compound GO:0071407 IDA
    response to dexamethasone GO:0071548 IEA
    endothelial cell-cell adhesion GO:0071603 IEA
    response to indole-3-methanol GO:0071680 IEA
    cellular response to toxic substance GO:0097237 IEA
    omega-hydroxylase P450 pathway GO:0097267 TAS
    response to 3-methylcholanthrene GO:1904681 IEA
    regulation of reactive oxygen species metabolic process GO:2000377 ISS
    positive regulation of reactive oxygen species metabolic process GO:2000379 IEA
    positive regulation of DNA biosynthetic process GO:2000573 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISS
    endoplasmic reticulum membrane GO:0005789 TAS
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified CYP1B1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CYP1B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SAE1 10055
Affinity Capture-MS Homo sapiens
2 HSPB2  
Two-hybrid Homo sapiens
3 DDX58 23586
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml



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