Gene description for CYP1B1
Gene name cytochrome P450, family 1, subfamily B, polypeptide 1
Gene symbol CYP1B1
Other names/aliases CP1B
CYPIB1
GLC3A
P4501B1
Species Homo sapiens
 Database cross references - CYP1B1
ExoCarta ExoCarta_1545
Vesiclepedia VP_1545
Entrez Gene 1545
HGNC 2597
MIM 601771
UniProt Q16678  
 CYP1B1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CYP1B1
Molecular Function
    monooxygenase activity GO:0004497 TAS
    iron ion binding GO:0005506 IEA
    aromatase activity GO:0070330 IEA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IDA
    oxygen binding GO:0019825 TAS
    heme binding GO:0020037 TAS
Biological Process
    xenobiotic metabolic process GO:0006805 TAS
    positive regulation of vascular endothelial growth factor production GO:0010575 ISS
    omega-hydroxylase P450 pathway GO:0097267 TAS
    blood vessel morphogenesis GO:0048514 ISS
    negative regulation of cell adhesion mediated by integrin GO:0033629 ISS
    sterol metabolic process GO:0016125 TAS
    arachidonic acid metabolic process GO:0019369 TAS
    steroid metabolic process GO:0008202 IDA
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISS
    toxin metabolic process GO:0009404 IEA
    collagen fibril organization GO:0030199 ISS
    estrogen metabolic process GO:0008210 IDA
    response to toxic substance GO:0009636 IEA
    small molecule metabolic process GO:0044281 TAS
    negative regulation of cell migration GO:0030336 ISS
    visual perception GO:0007601 TAS
    nitric oxide biosynthetic process GO:0006809 ISS
    retinol metabolic process GO:0042572 IDA
    cellular aromatic compound metabolic process GO:0006725 IEA
    endothelial cell-cell adhesion GO:0071603 IEA
    retinal metabolic process GO:0042574 IDA
    oxidation-reduction process GO:0055114 TAS
    regulation of reactive oxygen species metabolic process GO:2000377 ISS
    positive regulation of JAK-STAT cascade GO:0046427 ISS
    positive regulation of angiogenesis GO:0045766 ISS
    angiogenesis GO:0001525 IEA
    cellular response to hydrogen peroxide GO:0070301 ISS
    endothelial cell migration GO:0043542 ISS
    retinal blood vessel morphogenesis GO:0061304 ISS
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS
    cell adhesion GO:0007155 ISS
    membrane lipid catabolic process GO:0046466 ISS
    epoxygenase P450 pathway GO:0019373 TAS
    negative regulation of cell proliferation GO:0008285 ISS
    cellular response to organic cyclic compound GO:0071407 IDA
    positive regulation of apoptotic process GO:0043065 ISS
    trabecular meshwork development GO:0002930 ISS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    mitochondrion GO:0005739 ISS
 Experiment description of studies that identified CYP1B1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CYP1B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SAE1 10055
Affinity Capture-MS Homo sapiens
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