Gene description for Igf1r
Gene name insulin-like growth factor I receptor
Gene symbol Igf1r
Other names/aliases A330103N21Rik
CD221
D930020L01
IGF-1R
hyft
Species Mus musculus
 Database cross references - Igf1r
ExoCarta ExoCarta_16001
Vesiclepedia VP_16001
Entrez Gene 16001
UniProt Q60751  
 Igf1r identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Igf1r
Molecular Function
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    protein kinase activity GO:0004672 IEA
    kinase activity GO:0016301 IEA
    insulin binding GO:0043559 ISO
    insulin-like growth factor-activated receptor activity GO:0005010 ISO
    protein tyrosine kinase activity GO:0004713 ISO
    protein binding GO:0005515 IPI
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    insulin-like growth factor I binding GO:0031994 ISO
    ATP binding GO:0005524 IEA
    insulin receptor binding GO:0005158 ISO
    nucleotide binding GO:0000166 IEA
    insulin-like growth factor binding GO:0005520 ISO
    identical protein binding GO:0042802 ISO
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    insulin receptor substrate binding GO:0043560 ISO
    G-protein alpha-subunit binding GO:0001965 ISO
    transferase activity GO:0016740 IEA
Biological Process
    brain development GO:0007420 IMP
    peptidyl-tyrosine autophosphorylation GO:0038083 ISO
    phosphorylation GO:0016310 IEA
    exocrine pancreas development GO:0031017 IMP
    protein heterooligomerization GO:0051291 ISO
    positive regulation of DNA metabolic process GO:0051054 ISO
    male sex determination GO:0030238 IMP
    axonogenesis GO:0007409 ISO
    positive regulation of mitotic nuclear division GO:0045840 IMP
    prostate gland epithelium morphogenesis GO:0060740 IMP
    epidermis development GO:0008544 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    inactivation of MAPKK activity GO:0051389 ISO
    immune response GO:0006955 ISO
    negative regulation of muscle cell apoptotic process GO:0010656 ISO
    protein autophosphorylation GO:0046777 ISO
    negative regulation of MAPK cascade GO:0043409 IMP
    organ morphogenesis GO:0009887 IMP
    positive regulation of DNA replication GO:0045740 ISO
    establishment of cell polarity GO:0030010 ISO
    positive regulation of protein kinase B signaling GO:0051897 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 ISO
    neuron projection development GO:0031175 ISO
    protein phosphorylation GO:0006468 IDA
    positive regulation of cytokinesis GO:0032467 ISO
    mammary gland development GO:0030879 IMP
    protein tetramerization GO:0051262 ISO
    phosphatidylinositol-mediated signaling GO:0048015 ISO
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IMP
    positive regulation of MAPK cascade GO:0043410 IMP
    positive regulation of steroid hormone biosynthetic process GO:0090031 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of protein kinase B signaling GO:0051898 IMP
    positive regulation of cell migration GO:0030335 ISO
    regulation of JNK cascade GO:0046328 ISO
Subcellular Localization
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 ISO
    neuron projection GO:0043005 ISO
    receptor complex GO:0043235 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    integral component of membrane GO:0016021 IDA
    caveola GO:0005901 ISO
 Experiment description of studies that identified Igf1r in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Igf1r
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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