Gene description for Igfbp2
Gene name insulin-like growth factor binding protein 2
Gene symbol Igfbp2
Other names/aliases AI255832
IBP-2
Igfbp-2
mIGFBP-2
Species Mus musculus
 Database cross references - Igfbp2
ExoCarta ExoCarta_16008
Vesiclepedia VP_16008
Entrez Gene 16008
UniProt P47877  
 Igfbp2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Igfbp2
Molecular Function
    insulin-like growth factor II binding GO:0031995 ISO
    insulin-like growth factor binding GO:0005520 IPI
    growth factor binding GO:0019838 IEA
    insulin-like growth factor I binding GO:0031994 ISO
Biological Process
    positive regulation of activated T cell proliferation GO:0042104 ISO
    regulation of growth GO:0040008 IEA
    regulation of cell growth GO:0001558 IEA
    regulation of insulin-like growth factor receptor signaling pathway GO:0043567 IBA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasmic vesicle GO:0031410 ISO
    apical plasma membrane GO:0016324 ISO
    extracellular space GO:0005615 ISO
    extracellular region GO:0005576 ISO
 Experiment description of studies that identified Igfbp2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Igfbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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