Gene description for Itga3
Gene name integrin alpha 3
Gene symbol Itga3
Other names/aliases AA407068
Species Mus musculus
 Database cross references - Itga3
ExoCarta ExoCarta_16400
Entrez Gene 16400
UniProt Q62470  
 Itga3 identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Itga3
Molecular Function
    glycoprotein binding GO:0001948 ISO
    protein domain specific binding GO:0019904 ISO
    fibronectin binding GO:0001968 ISO
    protein binding GO:0005515 IPI
    protease binding GO:0002020 ISO
    laminin binding GO:0043236 ISO
    integrin binding GO:0005178 ISO
    collagen binding GO:0005518 ISO
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    negative regulation of Rho protein signal transduction GO:0035024 IGI
    cell adhesion GO:0007155 ISO
    regulation of Wnt signaling pathway GO:0030111 ISO
    positive regulation of epithelial cell migration GO:0010634 ISO
    integrin-mediated signaling pathway GO:0007229 IEA
    positive regulation of gene expression GO:0010628 ISO
    renal filtration GO:0097205 ISO
    skin development GO:0043588 ISO
    lung development GO:0030324 ISO
    nephron development GO:0072006 ISO
    dendritic spine maintenance GO:0097062 IMP
    negative regulation of cell projection organization GO:0031345 ISO
    positive regulation of neuron projection development GO:0010976 ISO
    exploration behavior GO:0035640 IGI
    memory GO:0007613 IMP
    positive regulation of cell-substrate adhesion GO:0010811 ISO
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 ISO
    regulation of BMP signaling pathway GO:0030510 ISO
    single-organism behavior GO:0044708 IMP
    neuron migration GO:0001764 IMP
    fusion of sperm to egg plasma membrane GO:0007342 IMP
    positive regulation of establishment of protein localization to plasma membrane GO:0090004 ISO
Subcellular Localization
    basolateral plasma membrane GO:0016323 IDA
    synaptic membrane GO:0097060 IDA
    membrane GO:0016020 IEA
    integrin complex GO:0008305 IEA
    excitatory synapse GO:0060076 IDA
    growth cone GO:0030426 ISO
    external side of plasma membrane GO:0009897 IDA
    integrin alpha3-beta1 complex GO:0034667 ISO
    plasma membrane GO:0005886 ISO
    filopodium membrane GO:0031527 ISO
    extracellular exosome GO:0070062 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cell projection GO:0042995 IEA
    cell surface GO:0009986 ISO
    integral component of membrane GO:0016021 IEA
    cell junction GO:0030054 IEA
    focal adhesion GO:0005925 ISO
    invadopodium membrane GO:0071438 ISO
    synapse GO:0045202 IDA
    cell periphery GO:0071944 ISO
    receptor complex GO:0043235 ISO
 Experiment description of studies that identified Itga3 in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Itga3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Itga3 is involved
Basigin interactions IEA Reactome
Integrin cell surface interactions IEA Reactome
Laminin interactions IEA Reactome

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