Gene description for Itgb5
Gene name integrin beta 5
Gene symbol Itgb5
Other names/aliases AA475909
AI874634
ESTM23
[b]-5
[b]5
[b]5A
[b]5B
beta-5
beta5
Species Mus musculus
 Database cross references - Itgb5
ExoCarta ExoCarta_16419
Vesiclepedia VP_16419
Entrez Gene 16419
UniProt O70309  
 Itgb5 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Itgb5
Molecular Function
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IPI
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 ISO
    cell-matrix adhesion GO:0007160 NAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    integrin-mediated signaling pathway GO:0007229 IBA
    integrin-mediated signaling pathway GO:0007229 IMP
    integrin-mediated signaling pathway GO:0007229 ISO
    integrin-mediated signaling pathway GO:0007229 NAS
    cell migration GO:0016477 IBA
    cell migration GO:0016477 ISO
    cell adhesion mediated by integrin GO:0033627 IBA
    wound healing, spreading of epidermal cells GO:0035313 NAS
    stress fiber assembly GO:0043149 IBA
    stress fiber assembly GO:0043149 IMP
    stress fiber assembly GO:0043149 ISO
    epithelial cell-cell adhesion GO:0090136 ISO
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IDA
    integrin complex GO:0008305 IBA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 ISO
    cell leading edge GO:0031252 IDA
    integrin alphav-beta5 complex GO:0034684 IDA
    integrin alphav-beta5 complex GO:0034684 ISO
    receptor complex GO:0043235 ISO
    synaptic membrane GO:0097060 IDA
    synaptic membrane GO:0097060 IEP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
 Experiment description of studies that identified Itgb5 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Itgb5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ltbp3  
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Ndn  
Two-hybrid Mus musculus
4 Mapk1 26413
Affinity Capture-Western Mus musculus
Protein-peptide Mus musculus
5 Tenc1  
Co-fractionation Mus musculus
6 Myo7a  
Co-fractionation Mus musculus
7 Gon4l 76022
Co-fractionation Mus musculus
8 Angptl4 57875
Co-fractionation Mus musculus
View the network image/svg+xml



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