Gene description for Itgb5
Gene name integrin beta 5
Gene symbol Itgb5
Other names/aliases AA475909
AI874634
ESTM23
[b]-5
[b]5
[b]5A
[b]5B
beta-5
beta5
Species Mus musculus
 Database cross references - Itgb5
ExoCarta ExoCarta_16419
Vesiclepedia VP_16419
Entrez Gene 16419
UniProt O70309  
 Itgb5 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Itgb5
Molecular Function
    receptor binding GO:0005102 ISO
    integrin binding GO:0005178 IPI
    receptor activity GO:0004872 IEA
    protein binding GO:0005515 IPI
Biological Process
    epithelial cell-cell adhesion GO:0090136 ISO
    stress fiber assembly GO:0043149 ISO
    integrin-mediated signaling pathway GO:0007229 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    cell adhesion GO:0007155 IEA
    cell-matrix adhesion GO:0007160 ISO
Subcellular Localization
    focal adhesion GO:0005925 ISO
    membrane GO:0016020 IEA
    receptor complex GO:0043235 ISO
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 ISO
    cell leading edge GO:0031252 IDA
    integrin complex GO:0008305 IEA
    cell surface GO:0009986 ISO
    integrin alphav-beta5 complex GO:0034684 ISO
 Experiment description of studies that identified Itgb5 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Itgb5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Itgb5 is involved
No pathways found





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