Gene description for Angptl4
Gene name angiopoietin-like 4
Gene symbol Angptl4
Other names/aliases Arp4
Bk89
Fiaf
Hfarp
Ng27
Pgar
Pgarg
Pp1158
Species Mus musculus
 Database cross references - Angptl4
ExoCarta ExoCarta_57875
Entrez Gene 57875
UniProt Q9Z1P8  
 Angptl4 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Angptl4
Molecular Function
    enzyme inhibitor activity GO:0004857 IDA
Biological Process
    negative regulation of apoptotic process GO:0043066 ISO
    angiogenesis GO:0001525 IEA
    protein homooligomerization GO:0051260 ISO
    positive regulation of lipid metabolic process GO:0045834 NAS
    negative regulation of lipoprotein lipase activity GO:0051005 ISO
    cellular response to starvation GO:0009267 NAS
    negative regulation of endothelial cell apoptotic process GO:2000352 IDA
    triglyceride homeostasis GO:0070328 IMP
Subcellular Localization
    blood microparticle GO:0072562 ISO
    extracellular region GO:0005576 ISO
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular space GO:0005615 ISA
 Experiment description of studies that identified Angptl4 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Angptl4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Angptl4 is involved
No pathways found





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