Gene description for Angptl4
Gene name angiopoietin-like 4
Gene symbol Angptl4
Other names/aliases Arp4
Bk89
Fiaf
Hfarp
Ng27
Pgar
Pgarg
Pp1158
Species Mus musculus
 Database cross references - Angptl4
ExoCarta ExoCarta_57875
Vesiclepedia VP_57875
Entrez Gene 57875
UniProt Q9Z1P8  
 Angptl4 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Angptl4
Molecular Function
    enzyme inhibitor activity GO:0004857 IBA
    enzyme inhibitor activity GO:0004857 IDA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    angiogenesis GO:0001525 IEA
    response to hypoxia GO:0001666 IEA
    lipid metabolic process GO:0006629 IEA
    blood coagulation GO:0007596 IEA
    cellular response to starvation GO:0009267 NAS
    negative regulation of apoptotic process GO:0043066 IDA
    negative regulation of apoptotic process GO:0043066 ISO
    protein unfolding GO:0043335 IEA
    protein unfolding GO:0043335 ISO
    positive regulation of lipid metabolic process GO:0045834 NAS
    negative regulation of lipoprotein lipase activity GO:0051005 IDA
    negative regulation of lipoprotein lipase activity GO:0051005 ISO
    triglyceride homeostasis GO:0070328 IBA
    triglyceride homeostasis GO:0070328 IMP
    endothelial cell apoptotic process GO:0072577 IDA
    negative regulation of endothelial cell apoptotic process GO:2000352 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    collagen-containing extracellular matrix GO:0062023 IBA
 Experiment description of studies that identified Angptl4 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Angptl4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Esr1  
Co-fractionation Mus musculus
2 Smarca4  
Co-fractionation Mus musculus
3 Itgb5 16419
Co-fractionation Mus musculus
View the network image/svg+xml



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